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Phosphorylation on Syk Y342 is important for both ITAM and hemITAM signaling in platelets

Immune cells express receptors bearing an immune tyrosine activation motif (ITAM) containing two YXXL motifs or hemITAMs containing only one YXXL motif. Phosphorylation of the ITAM/hemITAM is mediated by Src family kinases allowing for the binding and activation of spleen tyrosine kinase (Syk). It i...

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Detalles Bibliográficos
Autores principales:	Kostyak, John C., Mauri, Benjamin, Dangelmaier, Carol, Vari, Hymavathi Reddy, Patel, Akruti, Wright, Monica, Reddy, Haritha, Tsygankov, Alexander Y., Kunapuli, Satya P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287148/ https://www.ncbi.nlm.nih.gov/pubmed/35753354 http://dx.doi.org/10.1016/j.jbc.2022.102189

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