Cargando…

Letters to the editor: Nicotinic acetylcholine receptor ligands as potential targets for managing neuropathic pain induced by diabetic peripheral neuropathy

Diabetic peripheral neuropathy (DPN) is a medical condition that is progressively becoming more prevalent. The underlying cause of DPN is still unknown, although there have been several hypothesized mechanisms. There are current pharmaceutical treatments used to manage the pain, but their efficacy i...

Descripción completa

Detalles Bibliográficos
Autores principales: Westlake, Sarah, Jones, Matthew, Sharma, Krishna D., Xie, Jennifer Yanhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287153/
https://www.ncbi.nlm.nih.gov/pubmed/35855978
http://dx.doi.org/10.1016/j.ensci.2022.100416
_version_ 1784748188711780352
author Westlake, Sarah
Jones, Matthew
Sharma, Krishna D.
Xie, Jennifer Yanhua
author_facet Westlake, Sarah
Jones, Matthew
Sharma, Krishna D.
Xie, Jennifer Yanhua
author_sort Westlake, Sarah
collection PubMed
description Diabetic peripheral neuropathy (DPN) is a medical condition that is progressively becoming more prevalent. The underlying cause of DPN is still unknown, although there have been several hypothesized mechanisms. There are current pharmaceutical treatments used to manage the pain, but their efficacy is largely unsatisfactory and are often associated with serious adverse effects. This review will explore the evidence of a new potential target for treating DPN, the ligands for nicotinic acetylcholine receptors (nAChRs), specifically α4ꞵ2 agonists and α9α10 antagonists.
format Online
Article
Text
id pubmed-9287153
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-92871532022-07-17 Letters to the editor: Nicotinic acetylcholine receptor ligands as potential targets for managing neuropathic pain induced by diabetic peripheral neuropathy Westlake, Sarah Jones, Matthew Sharma, Krishna D. Xie, Jennifer Yanhua eNeurologicalSci Letters to the Editor Diabetic peripheral neuropathy (DPN) is a medical condition that is progressively becoming more prevalent. The underlying cause of DPN is still unknown, although there have been several hypothesized mechanisms. There are current pharmaceutical treatments used to manage the pain, but their efficacy is largely unsatisfactory and are often associated with serious adverse effects. This review will explore the evidence of a new potential target for treating DPN, the ligands for nicotinic acetylcholine receptors (nAChRs), specifically α4ꞵ2 agonists and α9α10 antagonists. Elsevier 2022-07-02 /pmc/articles/PMC9287153/ /pubmed/35855978 http://dx.doi.org/10.1016/j.ensci.2022.100416 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Letters to the Editor
Westlake, Sarah
Jones, Matthew
Sharma, Krishna D.
Xie, Jennifer Yanhua
Letters to the editor: Nicotinic acetylcholine receptor ligands as potential targets for managing neuropathic pain induced by diabetic peripheral neuropathy
title Letters to the editor: Nicotinic acetylcholine receptor ligands as potential targets for managing neuropathic pain induced by diabetic peripheral neuropathy
title_full Letters to the editor: Nicotinic acetylcholine receptor ligands as potential targets for managing neuropathic pain induced by diabetic peripheral neuropathy
title_fullStr Letters to the editor: Nicotinic acetylcholine receptor ligands as potential targets for managing neuropathic pain induced by diabetic peripheral neuropathy
title_full_unstemmed Letters to the editor: Nicotinic acetylcholine receptor ligands as potential targets for managing neuropathic pain induced by diabetic peripheral neuropathy
title_short Letters to the editor: Nicotinic acetylcholine receptor ligands as potential targets for managing neuropathic pain induced by diabetic peripheral neuropathy
title_sort letters to the editor: nicotinic acetylcholine receptor ligands as potential targets for managing neuropathic pain induced by diabetic peripheral neuropathy
topic Letters to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287153/
https://www.ncbi.nlm.nih.gov/pubmed/35855978
http://dx.doi.org/10.1016/j.ensci.2022.100416
work_keys_str_mv AT westlakesarah letterstotheeditornicotinicacetylcholinereceptorligandsaspotentialtargetsformanagingneuropathicpaininducedbydiabeticperipheralneuropathy
AT jonesmatthew letterstotheeditornicotinicacetylcholinereceptorligandsaspotentialtargetsformanagingneuropathicpaininducedbydiabeticperipheralneuropathy
AT sharmakrishnad letterstotheeditornicotinicacetylcholinereceptorligandsaspotentialtargetsformanagingneuropathicpaininducedbydiabeticperipheralneuropathy
AT xiejenniferyanhua letterstotheeditornicotinicacetylcholinereceptorligandsaspotentialtargetsformanagingneuropathicpaininducedbydiabeticperipheralneuropathy