Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening

Oxidative stress is a primary cause of cellular senescence and contributes to the etiology of numerous human diseases. Oxidative damage to telomeric DNA has been proposed to cause premature senescence by accelerating telomere shortening. Here, we tested this model directly using a precision chemopto...

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Detalles Bibliográficos
Autores principales: Barnes, Ryan P., de Rosa, Mariarosaria, Thosar, Sanjana A., Detwiler, Ariana C., Roginskaya, Vera, Van Houten, Bennett, Bruchez, Marcel P., Stewart-Ornstein, Jacob, Opresko, Patricia L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287163/
https://www.ncbi.nlm.nih.gov/pubmed/35773409
http://dx.doi.org/10.1038/s41594-022-00790-y

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