Cargando…
Designing sensitive viral diagnostics with machine learning
Design of nucleic acid-based viral diagnostics typically follows heuristic rules and, to contend with viral variation, focuses on a genome’s conserved regions. A design process could, instead, directly optimize diagnostic effectiveness using a learned model of sensitivity for targets and their varia...
Autores principales: | Metsky, Hayden C., Welch, Nicole L., Pillai, Priya P., Haradhvala, Nicholas J., Rumker, Laurie, Mantena, Sreekar, Zhang, Yibin B., Yang, David K., Ackerman, Cheri M., Weller, Juliane, Blainey, Paul C., Myhrvold, Cameron, Mitzenmacher, Michael, Sabeti, Pardis C. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group US
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287178/ https://www.ncbi.nlm.nih.gov/pubmed/35241837 http://dx.doi.org/10.1038/s41587-022-01213-5 |
Ejemplares similares
-
Model-directed generation of CRISPR-Cas13a guide RNAs designs artificial sequences that improve nucleic acid detection
por: Mantena, Sreekar, et al.
Publicado: (2023) -
Multiplexed detection of bacterial nucleic acids using Cas13 in droplet microarrays
por: Thakku, Sri Gowtham, et al.
Publicado: (2022) -
Massively multiplexed nucleic acid detection with Cas13
por: Ackerman, Cheri M., et al.
Publicado: (2020) -
Equipment-free detection of SARS-CoV-2 and Variants of Concern using Cas13
por: Arizti-Sanz, Jon, et al.
Publicado: (2021) -
Strengthening healthcare delivery with remote patient monitoring in the time of COVID-19
por: Mantena, Sreekar, et al.
Publicado: (2021)