Latest developments in the pathobiology of Ewing sarcoma

Ewing's sarcoma (ES) is an aggressive malignant tumor commonly affecting adolescents. The standard of care includes surgical treatment and systemic therapies, although ES patients often develop drug resistance, leading to disease progression. Tumorigenesis in Ewing's sarcoma has unique cha...

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Detalles Bibliográficos
Autores principales: Karlina, Irina, Schroeder, Brett A., Kirgizov, Kirill, Romantsova, Olga, Istranov, Andrey L., Nedorubov, Andrey, Timashev, Peter, Ulasov, Ilya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287185/
https://www.ncbi.nlm.nih.gov/pubmed/35855933
http://dx.doi.org/10.1016/j.jbo.2022.100440
Descripción
Sumario:Ewing's sarcoma (ES) is an aggressive malignant tumor commonly affecting adolescents. The standard of care includes surgical treatment and systemic therapies, although ES patients often develop drug resistance, leading to disease progression. Tumorigenesis in Ewing's sarcoma has unique characteristics that allow for the development of targeted therapeutics. New data on the role of oncogenic drivers in ES tumorigenesis, particularly in relation to treatment-induced stress, offers new therapeutic opportunities. This review summarizes the latest information on the clinically relevant oncogenes found in Ewing's sarcoma, their biological roles, and candidate targets for improving ES patient outcomes.

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