Pan-cancer analyses of synonymous mutations based on tissue-specific codon optimality

Codon optimality has been demonstrated to be an important determinant of mRNA stability and expression levels in multiple model organisms and human cell lines. However, tissue-specific codon optimality has not been developed to investigate how codon optimality is usually perturbed by somatic synonym...

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Detalles Bibliográficos
Autores principales: Ran, Xia, Xiao, Jinyuan, Cheng, Fang, Wang, Tao, Teng, Huajing, Sun, Zhongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287186/
https://www.ncbi.nlm.nih.gov/pubmed/35860410
http://dx.doi.org/10.1016/j.csbj.2022.07.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287186/
https://www.ncbi.nlm.nih.gov/pubmed/35860410
http://dx.doi.org/10.1016/j.csbj.2022.07.005

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