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Pan-cancer analyses of synonymous mutations based on tissue-specific codon optimality
Codon optimality has been demonstrated to be an important determinant of mRNA stability and expression levels in multiple model organisms and human cell lines. However, tissue-specific codon optimality has not been developed to investigate how codon optimality is usually perturbed by somatic synonym...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Research Network of Computational and Structural Biotechnology
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287186/ https://www.ncbi.nlm.nih.gov/pubmed/35860410 http://dx.doi.org/10.1016/j.csbj.2022.07.005 |