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Gut microbe-derived metabolite trimethylamine N-oxide activates PERK to drive fibrogenic mesenchymal differentiation

Intestinal dysbiosis is prominent in systemic sclerosis (SSc), but it remains unknown how it contributes to microvascular injury and fibrosis that are hallmarks of this disease. Trimethylamine (TMA) is generated by the gut microbiome and in the host converted by flavin-containing monooxygenase (FMO3...

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Detalles Bibliográficos
Autores principales:	Kim, Seok-Jo, Bale, Swarna, Verma, Priyanka, Wan, Qianqian, Ma, Feiyang, Gudjonsson, Johann E., Hazen, Stanley L., Harms, Paul W., Tsou, Pei-Suen, Khanna, Dinesh, Tsoi, Lam C., Gupta, Nilaksh, Ho, Karen J., Varga, John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287188/ https://www.ncbi.nlm.nih.gov/pubmed/35856022 http://dx.doi.org/10.1016/j.isci.2022.104669

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