Cargando…

Recent advances in nanoparticle-based targeting tactics for antibacterial photodynamic therapy

ABSTRACT: The rise of antibacterial drug resistance means treatment options are becoming increasingly limited. We must find ways to tackle these hard-to-treat drug-resistant and biofilm infections. With the lack of new antibacterial drugs (such as antibiotics) reaching the clinics, research has swit...

Descripción completa

Detalles Bibliográficos
Autores principales: Thomas-Moore, Brydie A., del Valle, Carla Arnau, Field, Robert A., Marín, María J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287206/
https://www.ncbi.nlm.nih.gov/pubmed/35384638
http://dx.doi.org/10.1007/s43630-022-00194-3
_version_ 1784748201066102784
author Thomas-Moore, Brydie A.
del Valle, Carla Arnau
Field, Robert A.
Marín, María J.
author_facet Thomas-Moore, Brydie A.
del Valle, Carla Arnau
Field, Robert A.
Marín, María J.
author_sort Thomas-Moore, Brydie A.
collection PubMed
description ABSTRACT: The rise of antibacterial drug resistance means treatment options are becoming increasingly limited. We must find ways to tackle these hard-to-treat drug-resistant and biofilm infections. With the lack of new antibacterial drugs (such as antibiotics) reaching the clinics, research has switched focus to exploring alternative strategies. One such strategy is antibacterial photodynamic therapy (aPDT), a system that relies on light, oxygen, and a non-toxic dye (photosensitiser) to generate cytotoxic reactive oxygen species. This technique has already been shown capable of handling both drug-resistant and biofilm infections but has limited clinical approval to date, which is in part due to the low bioavailability and selectivity of hydrophobic photosensitisers. Nanotechnology-based techniques have the potential to address the limitations of current aPDT, as already well-documented in anti-cancer PDT. Here, we review recent advances in nanoparticle-based targeting tactics for aPDT. GRAPHICAL ABSTRACT: [Image: see text]
format Online
Article
Text
id pubmed-9287206
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Springer International Publishing
record_format MEDLINE/PubMed
spelling pubmed-92872062022-07-17 Recent advances in nanoparticle-based targeting tactics for antibacterial photodynamic therapy Thomas-Moore, Brydie A. del Valle, Carla Arnau Field, Robert A. Marín, María J. Photochem Photobiol Sci Reviews ABSTRACT: The rise of antibacterial drug resistance means treatment options are becoming increasingly limited. We must find ways to tackle these hard-to-treat drug-resistant and biofilm infections. With the lack of new antibacterial drugs (such as antibiotics) reaching the clinics, research has switched focus to exploring alternative strategies. One such strategy is antibacterial photodynamic therapy (aPDT), a system that relies on light, oxygen, and a non-toxic dye (photosensitiser) to generate cytotoxic reactive oxygen species. This technique has already been shown capable of handling both drug-resistant and biofilm infections but has limited clinical approval to date, which is in part due to the low bioavailability and selectivity of hydrophobic photosensitisers. Nanotechnology-based techniques have the potential to address the limitations of current aPDT, as already well-documented in anti-cancer PDT. Here, we review recent advances in nanoparticle-based targeting tactics for aPDT. GRAPHICAL ABSTRACT: [Image: see text] Springer International Publishing 2022-04-06 2022 /pmc/articles/PMC9287206/ /pubmed/35384638 http://dx.doi.org/10.1007/s43630-022-00194-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Reviews
Thomas-Moore, Brydie A.
del Valle, Carla Arnau
Field, Robert A.
Marín, María J.
Recent advances in nanoparticle-based targeting tactics for antibacterial photodynamic therapy
title Recent advances in nanoparticle-based targeting tactics for antibacterial photodynamic therapy
title_full Recent advances in nanoparticle-based targeting tactics for antibacterial photodynamic therapy
title_fullStr Recent advances in nanoparticle-based targeting tactics for antibacterial photodynamic therapy
title_full_unstemmed Recent advances in nanoparticle-based targeting tactics for antibacterial photodynamic therapy
title_short Recent advances in nanoparticle-based targeting tactics for antibacterial photodynamic therapy
title_sort recent advances in nanoparticle-based targeting tactics for antibacterial photodynamic therapy
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287206/
https://www.ncbi.nlm.nih.gov/pubmed/35384638
http://dx.doi.org/10.1007/s43630-022-00194-3
work_keys_str_mv AT thomasmoorebrydiea recentadvancesinnanoparticlebasedtargetingtacticsforantibacterialphotodynamictherapy
AT delvallecarlaarnau recentadvancesinnanoparticlebasedtargetingtacticsforantibacterialphotodynamictherapy
AT fieldroberta recentadvancesinnanoparticlebasedtargetingtacticsforantibacterialphotodynamictherapy
AT marinmariaj recentadvancesinnanoparticlebasedtargetingtacticsforantibacterialphotodynamictherapy