Interleukin-35 promotes Breg expansion and interleukin-10 production in CD19(+) B cells in patients with ankylosing spondylitis

OBJECTIVE: IL-35 is a potent immunosuppressive and anti-inflammatory cytokine, consisting of a p35 subunit and an Epstein–Barr virus–induced gene 3 (EBI3) subunit, which suppresses CD4(+) effector T cell proliferation and promotes regulatory T cell (Treg) expansion. However, the effects of IL-35 on...

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Detalles Bibliográficos
Autores principales: Zhang, Yu, Wei, Sixi, Wu, Qingqing, Shen, Xue, Dai, Wanrong, Zhang, Zhiqi, Chen, Man, Huang, Hai, Ma, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287221/
https://www.ncbi.nlm.nih.gov/pubmed/35420296
http://dx.doi.org/10.1007/s10067-022-06137-8

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