Hybrid-control arm construction using historical trial data for an early-phase, randomized controlled trial in metastatic colorectal cancer

BACKGROUND: Treatment for metastatic colorectal cancer patients beyond the second line remains challenging, highlighting the need for early phase trials of combination therapies for patients who had disease progression during or following two prior lines of therapy. Leveraging hybrid control design...

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Detalles Bibliográficos
Autores principales: Li, Chen, Ferro, Ana, Mhatre, Shivani K., Lu, Danny, Lawrance, Marcus, Li, Xiao, Li, Shi, Allen, Simon, Desai, Jayesh, Fakih, Marwan, Cecchini, Michael, Pedersen, Katrina S., Kim, Tae You, Reyes-Rivera, Irmarie, Segal, Neil H., Lenain, Christelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287310/
https://www.ncbi.nlm.nih.gov/pubmed/35856081
http://dx.doi.org/10.1038/s43856-022-00155-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287310/
https://www.ncbi.nlm.nih.gov/pubmed/35856081
http://dx.doi.org/10.1038/s43856-022-00155-y

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