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Pyruvate and uridine rescue the metabolic profile of OXPHOS dysfunction

INTRODUCTION: Primary mitochondrial diseases (PMD) are a large, heterogeneous group of genetic disorders affecting mitochondrial function, mostly by disrupting the oxidative phosphorylation (OXPHOS) system. Understanding the cellular metabolic re-wiring occurring in PMD is crucial for the developmen...

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Detalles Bibliográficos
Autores principales:	Adant, Isabelle, Bird, Matthew, Decru, Bram, Windmolders, Petra, Wallays, Marie, de Witte, Peter, Rymen, Daisy, Witters, Peter, Vermeersch, Pieter, Cassiman, David, Ghesquière, Bart
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287363/ https://www.ncbi.nlm.nih.gov/pubmed/35772644 http://dx.doi.org/10.1016/j.molmet.2022.101537

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