Timing is everything: structural insights into the disease-linked Kv3 channels controlling fast action-potential firing in the brain

Kv3 channels enable neurons to fire at very high frequencies (>100 Hz) which is fundamental to brain development and our ability to make sense of the world at large. Cryo-EM and structure-function studies by Chi et al. now uncover Kv3 channel gating mechanisms and support new precision medicine a...

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Autor principal: Gunthorpe, Martin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287389/
https://www.ncbi.nlm.nih.gov/pubmed/35840565
http://dx.doi.org/10.1038/s41467-022-31537-4
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author_facet Gunthorpe, Martin J.
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description Kv3 channels enable neurons to fire at very high frequencies (>100 Hz) which is fundamental to brain development and our ability to make sense of the world at large. Cryo-EM and structure-function studies by Chi et al. now uncover Kv3 channel gating mechanisms and support new precision medicine approaches for CNS diseases.
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spelling pubmed-92873892022-07-17 Timing is everything: structural insights into the disease-linked Kv3 channels controlling fast action-potential firing in the brain Gunthorpe, Martin J. Nat Commun Comment Kv3 channels enable neurons to fire at very high frequencies (>100 Hz) which is fundamental to brain development and our ability to make sense of the world at large. Cryo-EM and structure-function studies by Chi et al. now uncover Kv3 channel gating mechanisms and support new precision medicine approaches for CNS diseases. Nature Publishing Group UK 2022-07-15 /pmc/articles/PMC9287389/ /pubmed/35840565 http://dx.doi.org/10.1038/s41467-022-31537-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Comment
Gunthorpe, Martin J.
Timing is everything: structural insights into the disease-linked Kv3 channels controlling fast action-potential firing in the brain
title Timing is everything: structural insights into the disease-linked Kv3 channels controlling fast action-potential firing in the brain
title_full Timing is everything: structural insights into the disease-linked Kv3 channels controlling fast action-potential firing in the brain
title_fullStr Timing is everything: structural insights into the disease-linked Kv3 channels controlling fast action-potential firing in the brain
title_full_unstemmed Timing is everything: structural insights into the disease-linked Kv3 channels controlling fast action-potential firing in the brain
title_short Timing is everything: structural insights into the disease-linked Kv3 channels controlling fast action-potential firing in the brain
title_sort timing is everything: structural insights into the disease-linked kv3 channels controlling fast action-potential firing in the brain
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287389/
https://www.ncbi.nlm.nih.gov/pubmed/35840565
http://dx.doi.org/10.1038/s41467-022-31537-4
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