Spatial organization of hydrophobic and charged residues affects protein thermal stability and binding affinity

What are the molecular determinants of protein–protein binding affinity and whether they are similar to those regulating fold stability are two major questions of molecular biology, whose answers bring important implications both from a theoretical and applicative point of view. Here, we analyze che...

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Detalles Bibliográficos
Autores principales: Desantis, Fausta, Miotto, Mattia, Di Rienzo, Lorenzo, Milanetti, Edoardo, Ruocco, Giancarlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287411/
https://www.ncbi.nlm.nih.gov/pubmed/35840609
http://dx.doi.org/10.1038/s41598-022-16338-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287411/
https://www.ncbi.nlm.nih.gov/pubmed/35840609
http://dx.doi.org/10.1038/s41598-022-16338-5

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