Hepatic non-parenchymal S100A9-TLR4-mTORC1 axis normalizes diabetic ketogenesis

Unrestrained ketogenesis leads to life-threatening ketoacidosis whose incidence is high in patients with diabetes. While insulin therapy reduces ketogenesis this approach is sub-optimal. Here, we report an insulin-independent pathway able to normalize diabetic ketogenesis. By generating insulin defi...

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Detalles Bibliográficos
Autores principales: Ursino, Gloria, Ramadori, Giorgio, Höfler, Anna, Odouard, Soline, Teixeira, Pryscila D. S., Visentin, Florian, Veyrat-Durebex, Christelle, Lucibello, Giulia, Firnkes, Raquel, Ricci, Serena, Vianna, Claudia R., Jia, Lin, Dirlewanger, Mirjam, Klee, Philippe, Elmquist, Joel K., Roth, Johannes, Vogl, Thomas, Schwitzgebel, Valérie M., Jornayvaz, François R., Boland, Andreas, Coppari, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287425/
https://www.ncbi.nlm.nih.gov/pubmed/35840613
http://dx.doi.org/10.1038/s41467-022-31803-5

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