Pharmacological inhibition of ALCAT1 mitigates amyotrophic lateral sclerosis by attenuating SOD1 protein aggregation

OBJECTIVE: Mutations in the copper-zinc superoxide dismutase (SOD1) gene cause familial amyotrophic lateral sclerosis (ALS), a progressive fatal neuromuscular disease characterized by motor neurons death and severe skeletal muscle degeneration. However, there is no effective treatment for this debil...

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Detalles Bibliográficos
Autores principales: Liu, Xueling, Zhang, Jun, Li, Jie, Song, Chengjie, Shi, Yuguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287437/
https://www.ncbi.nlm.nih.gov/pubmed/35772643
http://dx.doi.org/10.1016/j.molmet.2022.101536

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