E2F and STAT3 provide transcriptional synergy for histone variant H2AZ activation to sustain glioblastoma chromatin accessibility and tumorigenicity

The histone variant H2AZ is overexpressed in diverse cancer types where it facilitates the accessibility of transcriptional regulators to the promoters of cell cycle genes. However, the molecular basis for its dysregulation in cancer remains unknown. Here, we report that glioblastomas (GBM) and glio...

Descripción completa

Detalles Bibliográficos
Autores principales: Yoon, Jeehyun, Grinchuk, Oleg V., Tirado-Magallanes, Roberto, Ngian, Zhen Kai, Tay, Emmy Xue Yun, Chuah, You Heng, Lee, Bernice Woon Li, Feng, Jia, Crasta, Karen Carmelina, Ong, Chin Tong, Benoukraf, Touati, Ong, Derrick Sek Tong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287453/
https://www.ncbi.nlm.nih.gov/pubmed/35058574
http://dx.doi.org/10.1038/s41418-021-00926-5

Ejemplares similares

Ejemplares similares