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New-onset psychosis following COVID-19 infection in a patient with no psychiatric history: A longitudinal case report

BACKGROUND: Viral infection, including COVID-19, has been implicated as a potential cause of various neurobehavioral issues. An increasing number of case reports suggest that current or recent COVID-19 infection may cause new onset of psychotic symptoms in some individuals, potentially related to vi...

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Autores principales: Runyan, Matthew, Fawver, Jay, Coupe, Amanda, Drouin, Michelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287465/
https://www.ncbi.nlm.nih.gov/pubmed/36457730
http://dx.doi.org/10.1016/j.psycr.2022.100035
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author Runyan, Matthew
Fawver, Jay
Coupe, Amanda
Drouin, Michelle
author_facet Runyan, Matthew
Fawver, Jay
Coupe, Amanda
Drouin, Michelle
author_sort Runyan, Matthew
collection PubMed
description BACKGROUND: Viral infection, including COVID-19, has been implicated as a potential cause of various neurobehavioral issues. An increasing number of case reports suggest that current or recent COVID-19 infection may cause new onset of psychotic symptoms in some individuals, potentially related to viral inflammation or infection of the nervous system. CASE PRESENTATION: A 26-year-old woman with no psychiatric history presented with severe psychotic symptoms days after recovery from a mild COVID-19 infection. No other etiologies for psychosis were identified via diagnostic testing, review of medical history, or interviews with family. Her symptoms persisted for approximately two months, requiring three inpatient admissions, various medication trials, and ongoing outpatient follow-up. With continued use of quetiapine and lithium, she returned to living independently and working full-time, and discontinued all medication approximately nine months after symptom onset. CONCLUSION: The psychiatric and cognitive effects of COVID-19 infection are not yet fully understood. Given the widespread and ongoing nature of this pandemic, this remains an important focus of further investigation, especially within the context of potential long-term complications.
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spelling pubmed-92874652022-07-18 New-onset psychosis following COVID-19 infection in a patient with no psychiatric history: A longitudinal case report Runyan, Matthew Fawver, Jay Coupe, Amanda Drouin, Michelle Psychiatry Res Case Rep Article BACKGROUND: Viral infection, including COVID-19, has been implicated as a potential cause of various neurobehavioral issues. An increasing number of case reports suggest that current or recent COVID-19 infection may cause new onset of psychotic symptoms in some individuals, potentially related to viral inflammation or infection of the nervous system. CASE PRESENTATION: A 26-year-old woman with no psychiatric history presented with severe psychotic symptoms days after recovery from a mild COVID-19 infection. No other etiologies for psychosis were identified via diagnostic testing, review of medical history, or interviews with family. Her symptoms persisted for approximately two months, requiring three inpatient admissions, various medication trials, and ongoing outpatient follow-up. With continued use of quetiapine and lithium, she returned to living independently and working full-time, and discontinued all medication approximately nine months after symptom onset. CONCLUSION: The psychiatric and cognitive effects of COVID-19 infection are not yet fully understood. Given the widespread and ongoing nature of this pandemic, this remains an important focus of further investigation, especially within the context of potential long-term complications. Published by Elsevier B.V. 2022-12 2022-07-16 /pmc/articles/PMC9287465/ /pubmed/36457730 http://dx.doi.org/10.1016/j.psycr.2022.100035 Text en © 2022 Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Runyan, Matthew
Fawver, Jay
Coupe, Amanda
Drouin, Michelle
New-onset psychosis following COVID-19 infection in a patient with no psychiatric history: A longitudinal case report
title New-onset psychosis following COVID-19 infection in a patient with no psychiatric history: A longitudinal case report
title_full New-onset psychosis following COVID-19 infection in a patient with no psychiatric history: A longitudinal case report
title_fullStr New-onset psychosis following COVID-19 infection in a patient with no psychiatric history: A longitudinal case report
title_full_unstemmed New-onset psychosis following COVID-19 infection in a patient with no psychiatric history: A longitudinal case report
title_short New-onset psychosis following COVID-19 infection in a patient with no psychiatric history: A longitudinal case report
title_sort new-onset psychosis following covid-19 infection in a patient with no psychiatric history: a longitudinal case report
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287465/
https://www.ncbi.nlm.nih.gov/pubmed/36457730
http://dx.doi.org/10.1016/j.psycr.2022.100035
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