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A nanoparticle-based COVID-19 vaccine candidate elicits broad neutralizing antibodies and protects against SARS-CoV-2 infection

A vaccine candidate to SARS-CoV-2 was constructed by coupling the viral receptor binding domain (RBD) to the surface of the papaya mosaic virus (PapMV) nanoparticle (nano) to generate the RBD-PapMV vaccine. Immunization of mice with the coupled RBD-PapMV vaccine enhanced the antibody titers and the...

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Autores principales:	Olivera-Ugarte, Santa-Mariela, Bolduc, Marilène, Laliberté-Gagné, Marie-Ève, Blanchette, Léa-Jeanne, Garneau, Caroline, Fillion, Maude, Savard, Pierre, Dubuc, Isabelle, Flamand, Louis, Farnòs, Omar, Xu, Xingge, Kamen, Amine, Gilbert, Mégan, Rabezanahary, Henintsoa, Scarrone, Martina, Couture, Christian, Baz, Mariana, Leclerc, Denis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Authors. Published by Elsevier Inc. 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287509/ https://www.ncbi.nlm.nih.gov/pubmed/35850421 http://dx.doi.org/10.1016/j.nano.2022.102584

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