Pathogenic autoantibodies to IFN-γ act through the impedance of receptor assembly and Fc-mediated response

Anti-interferon (IFN)–γ autoantibodies (AIGAs) are a pathogenic factor in late-onset immunodeficiency with disseminated mycobacterial and other opportunistic infections. AIGAs block IFN-γ function, but their effects on IFN-γ signaling are unknown. Using a single-cell capture method, we isolated 19 I...

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Detalles Bibliográficos
Autores principales: Shih, Han-Po, Ding, Jing-Ya, Sotolongo Bellón, Junel, Lo, Yu-Fang, Chung, Pei-Han, Ting, He-Ting, Peng, Jhan-Jie, Wu, Tsai-Yi, Lin, Chia-Hao, Lo, Chia-Chi, Lin, You-Ning, Yeh, Chun-Fu, Chen, Jiun-Bo, Wu, Ting-Shu, Liu, Yuag-Meng, Kuo, Chen-Yen, Wang, Shang-Yu, Tu, Kun-Hua, Ng, Chau Yee, Lei, Wei-Te, Tsai, Yu-Huan, Chen, Jou-Han, Chuang, Ya-Ting, Huang, Jing-Yi, Rey, Félix A., Chen, Hung-Kai, Chang, Tse-Wen, Piehler, Jacob, Chi, Chih-Yu, Ku, Cheng-Lung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287643/
https://www.ncbi.nlm.nih.gov/pubmed/35833912
http://dx.doi.org/10.1084/jem.20212126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287643/
https://www.ncbi.nlm.nih.gov/pubmed/35833912
http://dx.doi.org/10.1084/jem.20212126

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