Delayed administration of nafamostat mesylate inhibits thrombin-mediated blood–spinal cord barrier breakdown during acute spinal cord injury in rats

BACKGROUND: Nafamostat mesylate (nafamostat, NM) is an FDA-approved serine protease inhibitor that exerts anti-neuroinflammation and neuroprotective effects following rat spinal cord injury (SCI). However, clinical translation of nafamostat has been limited by an unclear administration time window a...

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Detalles Bibliográficos
Autores principales: Zhao, Chenxi, Zhou, Tiangang, Zhao, Xiaoqing, Pang, Yilin, Li, Wenxiang, Fan, Baoyou, Li, Ming, Liu, Xinjie, Ma, Lei, Zhang, Jiawei, Sun, Chao, Shen, Wenyuan, Kong, Xiaohong, Yao, Xue, Feng, Shiqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287720/
https://www.ncbi.nlm.nih.gov/pubmed/35842640
http://dx.doi.org/10.1186/s12974-022-02531-w

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