The relationship between folic acid and colorectal cancer; a literature review

THE OBJECTIVE: this study aims to investigate the relationship between folic acid and colorectal cancer (CRC). METHODS: google scholar, Pubmed, Pubmed central were searched from 1994 to 2022 for articles on the association between folic acid and CRC using the combinations: folic acid and colorectal...

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Detalles Bibliográficos
Autores principales: Kherbek, Haidara, Daoud, Rima, Soueycatt, Tania, Soueycatt, Youssef, Ali, Zain, Ehsan, Julia, Alshehabi, Zuheir, Georgeos, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287768/
https://www.ncbi.nlm.nih.gov/pubmed/35855881
http://dx.doi.org/10.1016/j.amsu.2022.104170
Descripción
Sumario:THE OBJECTIVE: this study aims to investigate the relationship between folic acid and colorectal cancer (CRC). METHODS: google scholar, Pubmed, Pubmed central were searched from 1994 to 2022 for articles on the association between folic acid and CRC using the combinations: folic acid and colorectal cancer risk, folic acid and colorectal cancer survival, folic acid and colorectal cancer recurrence. MAIN MESSAGE: to describe and discuss the effect that folic acid might play on colorectal cancer (CRC) risk, recurrence and survivals, taking into account the possible differences between the men and women. CONCLUSION: Our article supports the idea that says: vit-B9 has a dual-modulator effect on CRC carcinogenesis. However, its role in preventing recurrence and improving survival rates remains unresolved with a possible potential role of folate metabolism genotype variations. Therefore, more evidence from clinical studies is needed.

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