The relationship between folic acid and colorectal cancer; a literature review

THE OBJECTIVE: this study aims to investigate the relationship between folic acid and colorectal cancer (CRC). METHODS: google scholar, Pubmed, Pubmed central were searched from 1994 to 2022 for articles on the association between folic acid and CRC using the combinations: folic acid and colorectal...

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Autores principales: Kherbek, Haidara, Daoud, Rima, Soueycatt, Tania, Soueycatt, Youssef, Ali, Zain, Ehsan, Julia, Alshehabi, Zuheir, Georgeos, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287768/
https://www.ncbi.nlm.nih.gov/pubmed/35855881
http://dx.doi.org/10.1016/j.amsu.2022.104170
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author Kherbek, Haidara
Daoud, Rima
Soueycatt, Tania
Soueycatt, Youssef
Ali, Zain
Ehsan, Julia
Alshehabi, Zuheir
Georgeos, Michael
author_facet Kherbek, Haidara
Daoud, Rima
Soueycatt, Tania
Soueycatt, Youssef
Ali, Zain
Ehsan, Julia
Alshehabi, Zuheir
Georgeos, Michael
author_sort Kherbek, Haidara
collection PubMed
description THE OBJECTIVE: this study aims to investigate the relationship between folic acid and colorectal cancer (CRC). METHODS: google scholar, Pubmed, Pubmed central were searched from 1994 to 2022 for articles on the association between folic acid and CRC using the combinations: folic acid and colorectal cancer risk, folic acid and colorectal cancer survival, folic acid and colorectal cancer recurrence. MAIN MESSAGE: to describe and discuss the effect that folic acid might play on colorectal cancer (CRC) risk, recurrence and survivals, taking into account the possible differences between the men and women. CONCLUSION: Our article supports the idea that says: vit-B9 has a dual-modulator effect on CRC carcinogenesis. However, its role in preventing recurrence and improving survival rates remains unresolved with a possible potential role of folate metabolism genotype variations. Therefore, more evidence from clinical studies is needed.
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spelling pubmed-92877682022-07-17 The relationship between folic acid and colorectal cancer; a literature review Kherbek, Haidara Daoud, Rima Soueycatt, Tania Soueycatt, Youssef Ali, Zain Ehsan, Julia Alshehabi, Zuheir Georgeos, Michael Ann Med Surg (Lond) Review THE OBJECTIVE: this study aims to investigate the relationship between folic acid and colorectal cancer (CRC). METHODS: google scholar, Pubmed, Pubmed central were searched from 1994 to 2022 for articles on the association between folic acid and CRC using the combinations: folic acid and colorectal cancer risk, folic acid and colorectal cancer survival, folic acid and colorectal cancer recurrence. MAIN MESSAGE: to describe and discuss the effect that folic acid might play on colorectal cancer (CRC) risk, recurrence and survivals, taking into account the possible differences between the men and women. CONCLUSION: Our article supports the idea that says: vit-B9 has a dual-modulator effect on CRC carcinogenesis. However, its role in preventing recurrence and improving survival rates remains unresolved with a possible potential role of folate metabolism genotype variations. Therefore, more evidence from clinical studies is needed. Elsevier 2022-07-12 /pmc/articles/PMC9287768/ /pubmed/35855881 http://dx.doi.org/10.1016/j.amsu.2022.104170 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Kherbek, Haidara
Daoud, Rima
Soueycatt, Tania
Soueycatt, Youssef
Ali, Zain
Ehsan, Julia
Alshehabi, Zuheir
Georgeos, Michael
The relationship between folic acid and colorectal cancer; a literature review
title The relationship between folic acid and colorectal cancer; a literature review
title_full The relationship between folic acid and colorectal cancer; a literature review
title_fullStr The relationship between folic acid and colorectal cancer; a literature review
title_full_unstemmed The relationship between folic acid and colorectal cancer; a literature review
title_short The relationship between folic acid and colorectal cancer; a literature review
title_sort relationship between folic acid and colorectal cancer; a literature review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287768/
https://www.ncbi.nlm.nih.gov/pubmed/35855881
http://dx.doi.org/10.1016/j.amsu.2022.104170
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