Hypoxia-inducible factor-1α and poly [ADP ribose] polymerase 1 cooperatively regulate Notch3 expression under hypoxia via a noncanonical mechanism

Upregulation of Notch3 expression has been reported in many cancers and is considered a marker for poor prognosis. Hypoxia is a driving factor of the Notch3 signaling pathway; however, the induction mechanism and role of hypoxia-inducible factor-1α (HIF-1α) in the Notch3 response are still unclear....

Descripción completa

Detalles Bibliográficos
Autores principales: Nakamura, Hideaki, Sekine, Hiroki, Kato, Hiroyuki, Masai, Hisao, Gradin, Katarina, Poellinger, Lorenz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287808/
https://www.ncbi.nlm.nih.gov/pubmed/35714766
http://dx.doi.org/10.1016/j.jbc.2022.102137

Ejemplares similares

Ejemplares similares