Siglec-15-induced autophagy promotes invasion and metastasis of human osteosarcoma cells by activating the epithelial–mesenchymal transition and Beclin-1/ATG14 pathway

BACKGROUND: Pulmonary metastasis is the main cause of poor prognosis in osteosarcoma. Sialic acid-bound immunoglobulin lectin 15 (Siglec-15) has been demonstrated to be obviously correlated with pulmonary metastasis in osteosarcoma patients. However, the effect of Siglec-15 on autophagy in osteosarc...

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Detalles Bibliográficos
Autores principales: Zheng, Bingxin, Song, Keliang, Sun, Lingling, Gao, Yang, Qu, Yan, Ren, Chongmin, Yan, Peng, Chen, Wenfang, Guo, Wei, Zhou, Chuanli, Yue, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287887/
https://www.ncbi.nlm.nih.gov/pubmed/35842729
http://dx.doi.org/10.1186/s13578-022-00846-y

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