Efficient and scalable synthesis of 1,5-diamino-2-hydroxy-pentane from l-lysine via cascade catalysis using engineered Escherichia coli

BACKGROUND: 1,5-Diamino-2-hydroxy-pentane (2-OH-PDA), as a new type of aliphatic amino alcohol, has potential applications in the pharmaceutical, chemical, and materials industries. Currently, 2-OH-PDA production has only been realized via pure enzyme catalysis from lysine hydroxylation and decarbox...

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Detalles Bibliográficos
Autores principales: Li, Yangyang, Zhang, Alei, Hu, Shewei, Chen, Kequan, Ouyang, Pingkai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288024/
https://www.ncbi.nlm.nih.gov/pubmed/35842631
http://dx.doi.org/10.1186/s12934-022-01864-8

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