LINE-1 promotes tumorigenicity and exacerbates tumor progression via stimulating metabolism reprogramming in non-small cell lung cancer

BACKGROUND: Long Interspersed Nuclear Element-1 (LINE-1, L1) is increasingly regarded as a genetic risk for lung cancer. Transcriptionally active LINE-1 forms a L1-gene chimeric transcript (LCTs), through somatic L1 retrotransposition (LRT) or L1 antisense promoter (L1-ASP) activation, to play an on...

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Detalles Bibliográficos
Autores principales: Sun, Zeguo, Zhang, Rui, Zhang, Xiao, Sun, Yifei, Liu, Pengpeng, Francoeur, Nancy, Han, Lei, Lam, Wan Yee, Yi, Zhengzi, Sebra, Robert, Walsh, Martin, Yu, Jinpu, Zhang, Weijia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288060/
https://www.ncbi.nlm.nih.gov/pubmed/35842613
http://dx.doi.org/10.1186/s12943-022-01618-5

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