Study protocol of a phase II study to evaluate safety and efficacy of neo-adjuvant pembrolizumab and radiotherapy in localized rectal cancer

BACKGROUND: Reshaping the tumor microenvironment by novel immunotherapies represents a key strategy to improve cancer treatment. Nevertheless, responsiveness to these treatments is often correlated with the extent of T cell infiltration at the tumor site. Remarkably, microsatellite stable rectal can...

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Detalles Bibliográficos
Autores principales: Corrò, Claudia, Buchs, Nicolas C., Tihy, Matthieu, Durham-Faivre, André, Bichard, Philippe, Frossard, Jean-Louis, Puppa, Giacomo, McKee, Thomas, Roth, Arnaud, Zilli, Thomas, Trembleau, Christelle, Di Marco, Mariagrazia, Dutoit, Valérie, Dietrich, Pierre-Yves, Ris, Frédéric, Koessler, Thibaud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288067/
https://www.ncbi.nlm.nih.gov/pubmed/35840912
http://dx.doi.org/10.1186/s12885-022-09820-w

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