Effectiveness of BBIBP-CorV, BNT162b2 and mRNA-1273 vaccines against hospitalisations among children and adolescents during the Omicron outbreak in Argentina: A retrospective cohort study

BACKGROUND: Although paediatric clinical presentations of COVID-19 are usually less severe than in adults, serious illness and death have occurred. Many countries started the vaccination rollout of children in 2021; still, information about effectiveness in the real-world setting is scarce. The aim...

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Detalles Bibliográficos
Autores principales: González, Soledad, Olszevicki, Santiago, Gaiano, Alejandra, Baino, Ana Nina Varela, Regairaz, Lorena, Salazar, Martín, Pesci, Santiago, Marín, Lupe, Martínez, Verónica V. González, Varela, Teresa, Ceriani, Leticia, Garcia, Enio, Kreplak, Nicolás, Navarro, Alexia, Estenssoro, Elisa, Marsico, Franco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288143/
https://www.ncbi.nlm.nih.gov/pubmed/35872665
http://dx.doi.org/10.1016/j.lana.2022.100316
Descripción
Sumario:BACKGROUND: Although paediatric clinical presentations of COVID-19 are usually less severe than in adults, serious illness and death have occurred. Many countries started the vaccination rollout of children in 2021; still, information about effectiveness in the real-world setting is scarce. The aim of our study was to evaluate vaccine effectiveness (VE) against COVID-19-associated-hospitalisations in the 3–17-year population during the Omicron outbreak. METHODS: We conducted a retrospective cohort study including individuals aged 3–17 registered in the online vaccination system of the Buenos Aires Province, Argentina. mRNA-1273 and BNT162b2 were administered to 12–17-year subjects; and BBIBP-CorV to 3–11-year subjects. Vaccinated group had received a two-dose scheme by 12/1/2021. Unvaccinated group did not receive any COVID-19 vaccine between 12/14/2021 and 3/9/2022, which was the entire monitoring period. Vaccine effectiveness (VE) against COVID-19-associated hospitalisations was calculated as (1-OR)x100. FINDINGS: By 12/1/2021, 1,536,435 individuals aged 3–17 who had received zero or two doses of SARS-CoV-2 vaccines were included in this study. Of the latter, 1,440,389 were vaccinated and 96,046 not vaccinated. VE were 78.0%[68.7–84.2], 76.4%[62.9–84.5] and 80.0%[64.3–88.0] for the entire cohort, 3–11-year (BBIBP-CorV) subgroup and 12–17 (mRNA vaccines) subgroup, respectively. VE for the entire population was 82.7% during the period of Delta and Omicron overlapping circulation and decreased to 67.7% when Omicron was the only variant present. INTERPRETATION: This report provides evidence of high vaccine protection against associated hospitalisations in the paediatric population during the Omicron outbreak but suggests a decrease of protection when Omicron became predominant. Application of a booster dose in children aged 3–11-year warrants further consideration. FUNDING: None.

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