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Can epicardial and pericardial adipose tissue volume predict the presence and severity of coronary artery disease?

PURPOSE: Excessive accumulation of free fatty acids in the coronary arteries can lead to coronary artery disease (CAD). Quantification of epicardial adipose tissue (EAT) and pericardial adipose tissue (PAT) is beneficial to understand its relationship with CAD, hypertension (HT), and diabetes. MATER...

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Autores principales: Panda, Sourav, Vimala, Leena Robinson, Livingstone, Roshan, Pearlin, Benedicta, Irodi, Aparna, Joseph, Elizabeth, George, Oommen K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288194/
https://www.ncbi.nlm.nih.gov/pubmed/35892072
http://dx.doi.org/10.5114/pjr.2022.117968
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author Panda, Sourav
Vimala, Leena Robinson
Livingstone, Roshan
Pearlin, Benedicta
Irodi, Aparna
Joseph, Elizabeth
George, Oommen K.
author_facet Panda, Sourav
Vimala, Leena Robinson
Livingstone, Roshan
Pearlin, Benedicta
Irodi, Aparna
Joseph, Elizabeth
George, Oommen K.
author_sort Panda, Sourav
collection PubMed
description PURPOSE: Excessive accumulation of free fatty acids in the coronary arteries can lead to coronary artery disease (CAD). Quantification of epicardial adipose tissue (EAT) and pericardial adipose tissue (PAT) is beneficial to understand its relationship with CAD, hypertension (HT), and diabetes. MATERIAL AND METHODS: This retrospective study included 54 patients who underwent CT coronary angiogram using a multidetector row CT scanner. The EAT and PAT volumes from cardiac images were quantified using Image J software. The severity of CAD was graded using the CAD-RADS score. RESULTS: Twenty-nine patients had no CAD, 21 patients had significant CAD, and 4 patients had insignificant CAD. Out of 21 patients with significant CAD, 14 had involvement of multiple coronary arteries. The EAT and PAT volumes were higher in patients with HT, DM, CAD-present group and significant-CAD-present group, but this was not statistically significant except the PAT volume with respect to diabetes. Significant correlation was found between EAT volume and calcium score (p = 0.035) and between EAT volume and total cholesterol level (p = 0.017). Significant differences in the EAT volumes were found in different CAD-RADS categories in the right coronary artery (RCA). From the threshold values, it was observed that CAD can develop in LAD even at lower of EAT and PAT volumes. CONCLUSIONS: Quantification of EAT and PAT volumes is beneficial in understanding its relationship with the presence and severity of coronary artery disease and its risk factors.
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spelling pubmed-92881942022-07-25 Can epicardial and pericardial adipose tissue volume predict the presence and severity of coronary artery disease? Panda, Sourav Vimala, Leena Robinson Livingstone, Roshan Pearlin, Benedicta Irodi, Aparna Joseph, Elizabeth George, Oommen K. Pol J Radiol Original Paper PURPOSE: Excessive accumulation of free fatty acids in the coronary arteries can lead to coronary artery disease (CAD). Quantification of epicardial adipose tissue (EAT) and pericardial adipose tissue (PAT) is beneficial to understand its relationship with CAD, hypertension (HT), and diabetes. MATERIAL AND METHODS: This retrospective study included 54 patients who underwent CT coronary angiogram using a multidetector row CT scanner. The EAT and PAT volumes from cardiac images were quantified using Image J software. The severity of CAD was graded using the CAD-RADS score. RESULTS: Twenty-nine patients had no CAD, 21 patients had significant CAD, and 4 patients had insignificant CAD. Out of 21 patients with significant CAD, 14 had involvement of multiple coronary arteries. The EAT and PAT volumes were higher in patients with HT, DM, CAD-present group and significant-CAD-present group, but this was not statistically significant except the PAT volume with respect to diabetes. Significant correlation was found between EAT volume and calcium score (p = 0.035) and between EAT volume and total cholesterol level (p = 0.017). Significant differences in the EAT volumes were found in different CAD-RADS categories in the right coronary artery (RCA). From the threshold values, it was observed that CAD can develop in LAD even at lower of EAT and PAT volumes. CONCLUSIONS: Quantification of EAT and PAT volumes is beneficial in understanding its relationship with the presence and severity of coronary artery disease and its risk factors. Termedia Publishing House 2022-06-26 /pmc/articles/PMC9288194/ /pubmed/35892072 http://dx.doi.org/10.5114/pjr.2022.117968 Text en © Pol J Radiol 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0). License (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Original Paper
Panda, Sourav
Vimala, Leena Robinson
Livingstone, Roshan
Pearlin, Benedicta
Irodi, Aparna
Joseph, Elizabeth
George, Oommen K.
Can epicardial and pericardial adipose tissue volume predict the presence and severity of coronary artery disease?
title Can epicardial and pericardial adipose tissue volume predict the presence and severity of coronary artery disease?
title_full Can epicardial and pericardial adipose tissue volume predict the presence and severity of coronary artery disease?
title_fullStr Can epicardial and pericardial adipose tissue volume predict the presence and severity of coronary artery disease?
title_full_unstemmed Can epicardial and pericardial adipose tissue volume predict the presence and severity of coronary artery disease?
title_short Can epicardial and pericardial adipose tissue volume predict the presence and severity of coronary artery disease?
title_sort can epicardial and pericardial adipose tissue volume predict the presence and severity of coronary artery disease?
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288194/
https://www.ncbi.nlm.nih.gov/pubmed/35892072
http://dx.doi.org/10.5114/pjr.2022.117968
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