Profiling the neurovascular unit unveils detrimental effects of osteopontin on the blood–brain barrier in acute ischemic stroke

Blood–brain barrier (BBB) dysfunction, characterized by degradation of BBB junctional proteins and increased permeability, is a crucial pathophysiological feature of acute ischemic stroke. Dysregulation of multiple neurovascular unit (NVU) cell types is involved in BBB breakdown in ischemic stroke t...

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Detalles Bibliográficos
Autores principales: Spitzer, Daniel, Guérit, Sylvaine, Puetz, Tim, Khel, Maryam I., Armbrust, Moritz, Dunst, Maika, Macas, Jadranka, Zinke, Jenny, Devraj, Gayatri, Jia, Xiaoxiong, Croll, Florian, Sommer, Kathleen, Filipski, Katharina, Freiman, Thomas M., Looso, Mario, Günther, Stefan, Di Tacchio, Mariangela, Plate, Karl-Heinz, Reiss, Yvonne, Liebner, Stefan, Harter, Patrick N., Devraj, Kavi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288377/
https://www.ncbi.nlm.nih.gov/pubmed/35752654
http://dx.doi.org/10.1007/s00401-022-02452-1

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