Dominant-acting CSF1R variants cause microglial depletion and altered astrocytic phenotype in zebrafish and adult-onset leukodystrophy

Tissue-resident macrophages of the brain, including microglia, are implicated in the pathogenesis of various CNS disorders and are possible therapeutic targets by their chemical depletion or replenishment by hematopoietic stem cell therapy. Nevertheless, a comprehensive understanding of microglial f...

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Detalles Bibliográficos
Autores principales: Berdowski, Woutje M., van der Linde, Herma C., Breur, Marjolein, Oosterhof, Nynke, Beerepoot, Shanice, Sanderson, Leslie, Wijnands, Lieve I., de Jong, Patrick, Tsai-Meu-Chong, Elisa, de Valk, Walter, de Witte, Moniek, van IJcken, Wilfred F. J., Demmers, Jeroen, van der Knaap, Marjo S., Bugiani, Marianna, Wolf, Nicole I., van Ham, Tjakko J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288387/
https://www.ncbi.nlm.nih.gov/pubmed/35713703
http://dx.doi.org/10.1007/s00401-022-02440-5

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