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The Effect of B-Cell Lymphoma 2 and BCL2-Associated X Polymorphisms on the Survival of Acute Lymphoblastic Leukemia Patients: Application of Frailty Survival Models

BACKGROUND: B-cell lymphoma 2 (BCL-2) and BCL-2 associated X (BAX) polymorphisms are important in the apoptosis process, response to treatment and survival in Acute Lymphoblastic Leukemia (ALL) patients. We aimed to investigate the effect of these genes with other predictors corresponding to the sur...

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Autores principales: Nikmohammadi, Navideh, Sarbakhsh, Parvin, Moazami Goudarzi, Mozghan, Talebi, Mehdi, Farshdousti-Hagh, Majid, Malakouti, Jamileh, Gilani, Neda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288405/
https://www.ncbi.nlm.nih.gov/pubmed/35936524
http://dx.doi.org/10.18502/ijph.v51i4.9251
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author Nikmohammadi, Navideh
Sarbakhsh, Parvin
Moazami Goudarzi, Mozghan
Talebi, Mehdi
Farshdousti-Hagh, Majid
Malakouti, Jamileh
Gilani, Neda
author_facet Nikmohammadi, Navideh
Sarbakhsh, Parvin
Moazami Goudarzi, Mozghan
Talebi, Mehdi
Farshdousti-Hagh, Majid
Malakouti, Jamileh
Gilani, Neda
author_sort Nikmohammadi, Navideh
collection PubMed
description BACKGROUND: B-cell lymphoma 2 (BCL-2) and BCL-2 associated X (BAX) polymorphisms are important in the apoptosis process, response to treatment and survival in Acute Lymphoblastic Leukemia (ALL) patients. We aimed to investigate the effect of these genes with other predictors corresponding to the survival of ALL patients with an appropriate frailty survival model. METHODS: Our study was performed in 2020 on sixty-two cases of childhood aged 3–16 (year) with ALL disease who were selected by convenience sampling from the two hospitals of Tabriz, Iran. RFLPPCR method was used for genotyping the promoter region of the BAX and BCL-2 genes. We used different frailty survival models, to control heterogeneity between individuals due to unmeasured factors affecting their survival. All analyses were implemented using Stata 16. RESULTS: Based on the result of log-logistic model along with frailty gamma, the proportional odds (standard error) of survival for a CC allele of BCL-2 patient compared to a AA allele patient were 6.0 (1.47); P<0.001 and for a AC of BCL-2 allele patient were 0.57 (1.23); P=0.009. Patients with AG allele of BAX had 2.05 (1.26) times greater odds of surviving than a AA allele patient (P=0.003). The odds of survival of patients with abnormal white blood cell (WBC) were 92% less than normal WBC (P<0.001). CONCLUSION: With controlling unmeasured factors affecting, the BCL-2 and BAX genes promoter polymorphism are effective in the survival rates for ALL.
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spelling pubmed-92884052022-08-04 The Effect of B-Cell Lymphoma 2 and BCL2-Associated X Polymorphisms on the Survival of Acute Lymphoblastic Leukemia Patients: Application of Frailty Survival Models Nikmohammadi, Navideh Sarbakhsh, Parvin Moazami Goudarzi, Mozghan Talebi, Mehdi Farshdousti-Hagh, Majid Malakouti, Jamileh Gilani, Neda Iran J Public Health Original Article BACKGROUND: B-cell lymphoma 2 (BCL-2) and BCL-2 associated X (BAX) polymorphisms are important in the apoptosis process, response to treatment and survival in Acute Lymphoblastic Leukemia (ALL) patients. We aimed to investigate the effect of these genes with other predictors corresponding to the survival of ALL patients with an appropriate frailty survival model. METHODS: Our study was performed in 2020 on sixty-two cases of childhood aged 3–16 (year) with ALL disease who were selected by convenience sampling from the two hospitals of Tabriz, Iran. RFLPPCR method was used for genotyping the promoter region of the BAX and BCL-2 genes. We used different frailty survival models, to control heterogeneity between individuals due to unmeasured factors affecting their survival. All analyses were implemented using Stata 16. RESULTS: Based on the result of log-logistic model along with frailty gamma, the proportional odds (standard error) of survival for a CC allele of BCL-2 patient compared to a AA allele patient were 6.0 (1.47); P<0.001 and for a AC of BCL-2 allele patient were 0.57 (1.23); P=0.009. Patients with AG allele of BAX had 2.05 (1.26) times greater odds of surviving than a AA allele patient (P=0.003). The odds of survival of patients with abnormal white blood cell (WBC) were 92% less than normal WBC (P<0.001). CONCLUSION: With controlling unmeasured factors affecting, the BCL-2 and BAX genes promoter polymorphism are effective in the survival rates for ALL. Tehran University of Medical Sciences 2022-04 /pmc/articles/PMC9288405/ /pubmed/35936524 http://dx.doi.org/10.18502/ijph.v51i4.9251 Text en Copyright © 2022 Nikmohammadi et al. Published by Tehran University of Medical Sciences https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International license (https://creativecommons.org/licenses/by-nc/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited.
spellingShingle Original Article
Nikmohammadi, Navideh
Sarbakhsh, Parvin
Moazami Goudarzi, Mozghan
Talebi, Mehdi
Farshdousti-Hagh, Majid
Malakouti, Jamileh
Gilani, Neda
The Effect of B-Cell Lymphoma 2 and BCL2-Associated X Polymorphisms on the Survival of Acute Lymphoblastic Leukemia Patients: Application of Frailty Survival Models
title The Effect of B-Cell Lymphoma 2 and BCL2-Associated X Polymorphisms on the Survival of Acute Lymphoblastic Leukemia Patients: Application of Frailty Survival Models
title_full The Effect of B-Cell Lymphoma 2 and BCL2-Associated X Polymorphisms on the Survival of Acute Lymphoblastic Leukemia Patients: Application of Frailty Survival Models
title_fullStr The Effect of B-Cell Lymphoma 2 and BCL2-Associated X Polymorphisms on the Survival of Acute Lymphoblastic Leukemia Patients: Application of Frailty Survival Models
title_full_unstemmed The Effect of B-Cell Lymphoma 2 and BCL2-Associated X Polymorphisms on the Survival of Acute Lymphoblastic Leukemia Patients: Application of Frailty Survival Models
title_short The Effect of B-Cell Lymphoma 2 and BCL2-Associated X Polymorphisms on the Survival of Acute Lymphoblastic Leukemia Patients: Application of Frailty Survival Models
title_sort effect of b-cell lymphoma 2 and bcl2-associated x polymorphisms on the survival of acute lymphoblastic leukemia patients: application of frailty survival models
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288405/
https://www.ncbi.nlm.nih.gov/pubmed/35936524
http://dx.doi.org/10.18502/ijph.v51i4.9251
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