The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis

The accurate repair of DNA double-strand breaks (DSBs), highly toxic DNA lesions, is crucial for genome integrity and is tightly regulated during the cell cycle. In mitosis, cells inactivate DSB repair in favor of a tethering mechanism that stabilizes broken chromosomes until they are repaired in th...

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Detalles Bibliográficos
Autores principales: De Marco Zompit, Mara, Esteban, Mònica Torres, Mooser, Clémence, Adam, Salomé, Rossi, Silvia Emma, Jeanrenaud, Alain, Leimbacher, Pia-Amata, Fink, Daniel, Shorrocks, Ann-Marie K., Blackford, Andrew N., Durocher, Daniel, Stucki, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288427/
https://www.ncbi.nlm.nih.gov/pubmed/35842428
http://dx.doi.org/10.1038/s41467-022-31865-5

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