ZnT8 loss-of-function accelerates functional maturation of hESC-derived β cells and resists metabolic stress in diabetes

Human embryonic stem cell-derived β cells (SC-β cells) hold great promise for treatment of diabetes, yet how to achieve functional maturation and protect them against metabolic stresses such as glucotoxicity and lipotoxicity remains elusive. Our single-cell RNA-seq analysis reveals that ZnT8 loss of...

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Detalles Bibliográficos
Autores principales: Ma, Qing, Xiao, Yini, Xu, Wenjun, Wang, Menghan, Li, Sheng, Yang, Zhihao, Xu, Minglu, Zhang, Tengjiao, Zhang, Zhen-Ning, Hu, Rui, Su, Qiang, Yuan, Fei, Xiao, Tinghui, Wang, Xuan, He, Qing, Zhao, Jiaxu, Chen, Zheng-jun, Sheng, Zhejin, Chai, Mengyao, Wang, Hong, Shi, Weiyang, Deng, Qiaolin, Cheng, Xin, Li, Weida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288460/
https://www.ncbi.nlm.nih.gov/pubmed/35842441
http://dx.doi.org/10.1038/s41467-022-31829-9

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