Lysosomal protein transmembrane 5 promotes lung-specific metastasis by regulating BMPR1A lysosomal degradation

Organotropism during cancer metastasis occurs frequently but the underlying mechanism remains poorly understood. Here, we show that lysosomal protein transmembrane 5 (LAPTM5) promotes lung-specific metastasis in renal cancer. LAPTM5 sustains self-renewal and cancer stem cell-like traits of renal can...

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Detalles Bibliográficos
Autores principales: Jiang, Bo, Zhao, Xiaozhi, Chen, Wei, Diao, Wenli, Ding, Meng, Qin, Haixiang, Li, Binghua, Cao, Wenmin, Fu, Yao, He, Kuiqiang, Gao, Jie, Chen, Mengxia, Lin, Tingsheng, Deng, Yongming, Yan, Chao, Guo, Hongqian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288479/
https://www.ncbi.nlm.nih.gov/pubmed/35842443
http://dx.doi.org/10.1038/s41467-022-31783-6

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