Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance

Enhancing the removal of aggregate-prone toxic proteins is a rational therapeutic strategy for a number of neurodegenerative diseases, especially Huntington’s disease and various spinocerebellar ataxias. Ideally, such approaches should preferentially clear the mutant/misfolded species, while having...

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Detalles Bibliográficos
Autores principales: Wrobel, Lidia, Hill, Sandra M., Djajadikerta, Alvin, Fernandez-Estevez, Marian, Karabiyik, Cansu, Ashkenazi, Avraham, Barratt, Victoria J., Stamatakou, Eleanna, Gunnarsson, Anders, Rasmusson, Timothy, Miele, Eric W., Beaton, Nigel, Bruderer, Roland, Feng, Yuehan, Reiter, Lukas, Castaldi, M. Paola, Jarvis, Rebecca, Tan, Keith, Bürli, Roland W., Rubinsztein, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288506/
https://www.ncbi.nlm.nih.gov/pubmed/35842429
http://dx.doi.org/10.1038/s41467-022-31905-0

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