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CRISPR-Cas12a nucleases function with structurally engineered crRNAs: SynThetic trAcrRNA

CRISPR-Cas12a systems are becoming an attractive genome editing tool for cell engineering due to their broader editing capabilities compared to CRISPR-Cas9 counterparts. As opposed to Cas9, the Cas12a endonucleases are characterized by a lack of trans-activating crRNA (tracrRNA), which reduces the c...

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Detalles Bibliográficos
Autores principales:	Jedrzejczyk, D. J., Poulsen, L. D., Mohr, M., Damas, N. D., Schoffelen, S., Barghetti, A., Baumgartner, R., Weinert, B. T., Warnecke, T., Gill, R. T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288538/ https://www.ncbi.nlm.nih.gov/pubmed/35842430 http://dx.doi.org/10.1038/s41598-022-15388-z

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