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A pan-cancer analysis of thioredoxin-interacting protein as an immunological and prognostic biomarker

BACKGROUND: The critical role of thioredoxin-interacting protein (TXNIP) in cellular sulfhydryl redox homeostasis and inflammasome activation is already widely known, however, no pan-cancer analysis is currently available. METHODS: We thus first explored the potential roles of TXNIP across thirty-th...

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Autores principales: Guo, Xuxue, Huang, Mei, Zhang, Haonan, Chen, Qianhui, Hu, Ying, Meng, Yan, Wu, Changjie, Tu, Chenge, Liu, Yongfeng, Li, Aimin, Li, Qingyuan, Zhou, Peirong, Liu, Side
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288722/
https://www.ncbi.nlm.nih.gov/pubmed/35843949
http://dx.doi.org/10.1186/s12935-022-02639-2
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author Guo, Xuxue
Huang, Mei
Zhang, Haonan
Chen, Qianhui
Hu, Ying
Meng, Yan
Wu, Changjie
Tu, Chenge
Liu, Yongfeng
Li, Aimin
Li, Qingyuan
Zhou, Peirong
Liu, Side
author_facet Guo, Xuxue
Huang, Mei
Zhang, Haonan
Chen, Qianhui
Hu, Ying
Meng, Yan
Wu, Changjie
Tu, Chenge
Liu, Yongfeng
Li, Aimin
Li, Qingyuan
Zhou, Peirong
Liu, Side
author_sort Guo, Xuxue
collection PubMed
description BACKGROUND: The critical role of thioredoxin-interacting protein (TXNIP) in cellular sulfhydryl redox homeostasis and inflammasome activation is already widely known, however, no pan-cancer analysis is currently available. METHODS: We thus first explored the potential roles of TXNIP across thirty-three tumors mainly based on The Cancer Genome Atlas and Gene Expression Omnibus datasets. RESULTS: TXNIP is lowly expressed in most cancers, and distinct associations exist between TXNIP expression and the prognosis of tumor patients. TXNIP expression was associated with tumor mutational burden, microsatellite instability, mismatch repair genes, tumor infiltrating immune cell abundance as well as cancer-associated fibroblasts. Moreover, ubiquitin mediated proteolysis, protein post-translational modification and other related pathways were involved in the functional mechanisms of TXNIP. CONCLUSIONS: Our first pan-cancer study comprehensively revealed the carcinostatic role of TXNIP across different tumors. And this molecule may be considered as a potential immunological and prognostic biomarker. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12935-022-02639-2.
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spelling pubmed-92887222022-07-18 A pan-cancer analysis of thioredoxin-interacting protein as an immunological and prognostic biomarker Guo, Xuxue Huang, Mei Zhang, Haonan Chen, Qianhui Hu, Ying Meng, Yan Wu, Changjie Tu, Chenge Liu, Yongfeng Li, Aimin Li, Qingyuan Zhou, Peirong Liu, Side Cancer Cell Int Research BACKGROUND: The critical role of thioredoxin-interacting protein (TXNIP) in cellular sulfhydryl redox homeostasis and inflammasome activation is already widely known, however, no pan-cancer analysis is currently available. METHODS: We thus first explored the potential roles of TXNIP across thirty-three tumors mainly based on The Cancer Genome Atlas and Gene Expression Omnibus datasets. RESULTS: TXNIP is lowly expressed in most cancers, and distinct associations exist between TXNIP expression and the prognosis of tumor patients. TXNIP expression was associated with tumor mutational burden, microsatellite instability, mismatch repair genes, tumor infiltrating immune cell abundance as well as cancer-associated fibroblasts. Moreover, ubiquitin mediated proteolysis, protein post-translational modification and other related pathways were involved in the functional mechanisms of TXNIP. CONCLUSIONS: Our first pan-cancer study comprehensively revealed the carcinostatic role of TXNIP across different tumors. And this molecule may be considered as a potential immunological and prognostic biomarker. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12935-022-02639-2. BioMed Central 2022-07-17 /pmc/articles/PMC9288722/ /pubmed/35843949 http://dx.doi.org/10.1186/s12935-022-02639-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Guo, Xuxue
Huang, Mei
Zhang, Haonan
Chen, Qianhui
Hu, Ying
Meng, Yan
Wu, Changjie
Tu, Chenge
Liu, Yongfeng
Li, Aimin
Li, Qingyuan
Zhou, Peirong
Liu, Side
A pan-cancer analysis of thioredoxin-interacting protein as an immunological and prognostic biomarker
title A pan-cancer analysis of thioredoxin-interacting protein as an immunological and prognostic biomarker
title_full A pan-cancer analysis of thioredoxin-interacting protein as an immunological and prognostic biomarker
title_fullStr A pan-cancer analysis of thioredoxin-interacting protein as an immunological and prognostic biomarker
title_full_unstemmed A pan-cancer analysis of thioredoxin-interacting protein as an immunological and prognostic biomarker
title_short A pan-cancer analysis of thioredoxin-interacting protein as an immunological and prognostic biomarker
title_sort pan-cancer analysis of thioredoxin-interacting protein as an immunological and prognostic biomarker
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288722/
https://www.ncbi.nlm.nih.gov/pubmed/35843949
http://dx.doi.org/10.1186/s12935-022-02639-2
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