ISG15 deficiency features a complex cellular phenotype that responds to treatment with itaconate and derivatives

BACKGROUND: Congenital ISG15 deficiency is a rare autoinflammatory disorder that is driven by chronically elevated systemic interferon levels and predominantly affects central nervous system and skin. METHODS AND RESULTS: We have developed induced pluripotent stem cell‐derived macrophages and endoth...

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Detalles Bibliográficos
Autores principales: Waqas, Syed Fakhar‐ul‐Hassnain, Sohail, Aaqib, Nguyen, Ariane Hai Ha, Usman, Abdulai, Ludwig, Tobias, Wegner, Andre, Malik, Muhammad Nasir Hayat, Schuchardt, Sven, Geffers, Robert, Winterhoff, Moritz, Merkert, Sylvia, Martin, Ulrich, Olmer, Ruth, Lachmann, Nico, Pessler, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288839/
https://www.ncbi.nlm.nih.gov/pubmed/35842904
http://dx.doi.org/10.1002/ctm2.931

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