Patient Derived Organoids Confirm That PI3K/AKT Signalling Is an Escape Pathway for Radioresistance and a Target for Therapy in Rectal Cancer

OBJECTIVES: Partial or total resistance to preoperative chemoradiotherapy occurs in more than half of locally advanced rectal cancer patients. Several novel or repurposed drugs have been trialled to improve cancer cell sensitivity to radiotherapy, with limited success. We aimed to understand the mec...

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Detalles Bibliográficos
Autores principales: Wanigasooriya, Kasun, Barros-Silva, Joao D., Tee, Louise, El-asrag, Mohammed E., Stodolna, Agata, Pickles, Oliver J., Stockton, Joanne, Bryer, Claire, Hoare, Rachel, Whalley, Celina M., Tyler, Robert, Sillo, Toritseju, Yau, Christopher, Ismail, Tariq, Beggs, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289101/
https://www.ncbi.nlm.nih.gov/pubmed/35860583
http://dx.doi.org/10.3389/fonc.2022.920444

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