RNA N(6)-Methyladenine Modification, Cellular Reprogramming, and Cancer Stemness

N(6)-Methyladenosine (m(6)A) is the most abundant modification on eukaryote messenger RNA and plays a key role in posttranscriptional regulation of RNA metabolism including splicing, intracellular transport, degradation, and translation. m(6)A is dynamically regulated by methyltransferases (writers)...

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Autores principales: Chen, Huarong, Wang, Yifei, Su, Hao, Zhang, Xiaoting, Chen, Hongyan, Yu, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289108/
https://www.ncbi.nlm.nih.gov/pubmed/35859892
http://dx.doi.org/10.3389/fcell.2022.935224
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author Chen, Huarong
Wang, Yifei
Su, Hao
Zhang, Xiaoting
Chen, Hongyan
Yu, Jun
author_facet Chen, Huarong
Wang, Yifei
Su, Hao
Zhang, Xiaoting
Chen, Hongyan
Yu, Jun
author_sort Chen, Huarong
collection PubMed
description N(6)-Methyladenosine (m(6)A) is the most abundant modification on eukaryote messenger RNA and plays a key role in posttranscriptional regulation of RNA metabolism including splicing, intracellular transport, degradation, and translation. m(6)A is dynamically regulated by methyltransferases (writers), RNA-binding proteins (readers), and demethylases (erasers). Recent studies demonstrate that perturbation of m(6)A regulators remarkably influences cell fate transitions through rewiring various biological processes, such as growth, differentiation, and survival. Moreover, aberrant m(6)A modification is implicated in a variety of diseases, in particular cancer. In this review, we describe the functional linkage of m(6)A modifications to cellular reprogramming and cancer stemness properties.
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spelling pubmed-92891082022-07-19 RNA N(6)-Methyladenine Modification, Cellular Reprogramming, and Cancer Stemness Chen, Huarong Wang, Yifei Su, Hao Zhang, Xiaoting Chen, Hongyan Yu, Jun Front Cell Dev Biol Cell and Developmental Biology N(6)-Methyladenosine (m(6)A) is the most abundant modification on eukaryote messenger RNA and plays a key role in posttranscriptional regulation of RNA metabolism including splicing, intracellular transport, degradation, and translation. m(6)A is dynamically regulated by methyltransferases (writers), RNA-binding proteins (readers), and demethylases (erasers). Recent studies demonstrate that perturbation of m(6)A regulators remarkably influences cell fate transitions through rewiring various biological processes, such as growth, differentiation, and survival. Moreover, aberrant m(6)A modification is implicated in a variety of diseases, in particular cancer. In this review, we describe the functional linkage of m(6)A modifications to cellular reprogramming and cancer stemness properties. Frontiers Media S.A. 2022-07-04 /pmc/articles/PMC9289108/ /pubmed/35859892 http://dx.doi.org/10.3389/fcell.2022.935224 Text en Copyright © 2022 Chen, Wang, Su, Zhang, Chen and Yu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Chen, Huarong
Wang, Yifei
Su, Hao
Zhang, Xiaoting
Chen, Hongyan
Yu, Jun
RNA N(6)-Methyladenine Modification, Cellular Reprogramming, and Cancer Stemness
title RNA N(6)-Methyladenine Modification, Cellular Reprogramming, and Cancer Stemness
title_full RNA N(6)-Methyladenine Modification, Cellular Reprogramming, and Cancer Stemness
title_fullStr RNA N(6)-Methyladenine Modification, Cellular Reprogramming, and Cancer Stemness
title_full_unstemmed RNA N(6)-Methyladenine Modification, Cellular Reprogramming, and Cancer Stemness
title_short RNA N(6)-Methyladenine Modification, Cellular Reprogramming, and Cancer Stemness
title_sort rna n(6)-methyladenine modification, cellular reprogramming, and cancer stemness
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289108/
https://www.ncbi.nlm.nih.gov/pubmed/35859892
http://dx.doi.org/10.3389/fcell.2022.935224
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