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Identification of Key Biomarkers in Systemic Lupus Erythematosus by a Multi-Cohort Analysis
Systemic lupus erythematosus (SLE) is an autoimmune disease that affects multiple body systems with heterogeneous clinical manifestations. Since gene expression analyses have been accomplished on diverse types of samples to specify SLE-related genes, single-cohort transcriptomics have not produced r...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289109/ https://www.ncbi.nlm.nih.gov/pubmed/35860258 http://dx.doi.org/10.3389/fimmu.2022.928623 |
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author | Wei, Meilin Dong, Qiguan Chen, Shaoqiu Wang, Junlong Yang, Hua Xiong, Qin |
author_facet | Wei, Meilin Dong, Qiguan Chen, Shaoqiu Wang, Junlong Yang, Hua Xiong, Qin |
author_sort | Wei, Meilin |
collection | PubMed |
description | Systemic lupus erythematosus (SLE) is an autoimmune disease that affects multiple body systems with heterogeneous clinical manifestations. Since gene expression analyses have been accomplished on diverse types of samples to specify SLE-related genes, single-cohort transcriptomics have not produced reliable results. Using an integrated multi-cohort analysis framework, we analyzed whole blood cells from SLE patients from three transcriptomics cohorts (n=1222) and identified a five-gene signature that distinguished SLE patients from controls. We validated the diagnostic performance of this five-gene signature in six independent validation cohorts (n= 469), with an area under the receiver operating characteristic curve of 0.88 [95% CI 0.7 − 0.96]. This five-gene signature may be associated with the proportion of SLE immune cells, and generalizable across ages and sample types with real diagnostic value for clinical application. |
format | Online Article Text |
id | pubmed-9289109 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92891092022-07-19 Identification of Key Biomarkers in Systemic Lupus Erythematosus by a Multi-Cohort Analysis Wei, Meilin Dong, Qiguan Chen, Shaoqiu Wang, Junlong Yang, Hua Xiong, Qin Front Immunol Immunology Systemic lupus erythematosus (SLE) is an autoimmune disease that affects multiple body systems with heterogeneous clinical manifestations. Since gene expression analyses have been accomplished on diverse types of samples to specify SLE-related genes, single-cohort transcriptomics have not produced reliable results. Using an integrated multi-cohort analysis framework, we analyzed whole blood cells from SLE patients from three transcriptomics cohorts (n=1222) and identified a five-gene signature that distinguished SLE patients from controls. We validated the diagnostic performance of this five-gene signature in six independent validation cohorts (n= 469), with an area under the receiver operating characteristic curve of 0.88 [95% CI 0.7 − 0.96]. This five-gene signature may be associated with the proportion of SLE immune cells, and generalizable across ages and sample types with real diagnostic value for clinical application. Frontiers Media S.A. 2022-07-04 /pmc/articles/PMC9289109/ /pubmed/35860258 http://dx.doi.org/10.3389/fimmu.2022.928623 Text en Copyright © 2022 Wei, Dong, Chen, Wang, Yang and Xiong https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Wei, Meilin Dong, Qiguan Chen, Shaoqiu Wang, Junlong Yang, Hua Xiong, Qin Identification of Key Biomarkers in Systemic Lupus Erythematosus by a Multi-Cohort Analysis |
title | Identification of Key Biomarkers in Systemic Lupus Erythematosus by a Multi-Cohort Analysis |
title_full | Identification of Key Biomarkers in Systemic Lupus Erythematosus by a Multi-Cohort Analysis |
title_fullStr | Identification of Key Biomarkers in Systemic Lupus Erythematosus by a Multi-Cohort Analysis |
title_full_unstemmed | Identification of Key Biomarkers in Systemic Lupus Erythematosus by a Multi-Cohort Analysis |
title_short | Identification of Key Biomarkers in Systemic Lupus Erythematosus by a Multi-Cohort Analysis |
title_sort | identification of key biomarkers in systemic lupus erythematosus by a multi-cohort analysis |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289109/ https://www.ncbi.nlm.nih.gov/pubmed/35860258 http://dx.doi.org/10.3389/fimmu.2022.928623 |
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