Heat Shock Transcription Factor 2 Promotes Mitophagy of Intestinal Epithelial Cells Through PARL/PINK1/Parkin Pathway in Ulcerative Colitis

The overactivation of NLRP3 inflammasome in intestinal epithelial cells (IECs) is among the important reasons for severe inflammation in ulcerative colitis (UC). We found that heat shock transcription factor 2 (HSF2), which is highly expressed in UC, could inhibit the activation of NLRP3 inflammasom...

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Detalles Bibliográficos
Autores principales: Liang, Hao, Zhang, Fengrui, Wang, Wen, Zhao, Wei, Zhou, Jiao, Feng, Yuran, Wu, Jing, Li, Maojuan, Bai, Xinyu, Zeng, Zhong, Niu, Junkun, Miao, Yinglei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289131/
https://www.ncbi.nlm.nih.gov/pubmed/35860016
http://dx.doi.org/10.3389/fphar.2022.893426

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