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Relationship Between Gender Differences and Clinical Outcome in Patients With the Antiphospholipid Syndrome

Antiphospholipid syndrome (APS), characterized by artherial and/or venous thrombosis, pregnancy morbidity and “antiphospholipid” antibodies (aPLs), is more common in women than in men, with a female to male ratio of about 3.5:1. Only few studies have investigated the clinical differences between mal...

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Autores principales: Truglia, Simona, Capozzi, Antonella, Mancuso, Silvia, Manganelli, Valeria, Rapino, Luca, Riitano, Gloria, Recalchi, Serena, Colafrancesco, Serena, Ceccarelli, Fulvia, Garofalo, Tina, Alessandri, Cristiano, Longo, Agostina, Misasi, Roberta, Conti, Fabrizio, Sorice, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289158/
https://www.ncbi.nlm.nih.gov/pubmed/35860235
http://dx.doi.org/10.3389/fimmu.2022.932181
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author Truglia, Simona
Capozzi, Antonella
Mancuso, Silvia
Manganelli, Valeria
Rapino, Luca
Riitano, Gloria
Recalchi, Serena
Colafrancesco, Serena
Ceccarelli, Fulvia
Garofalo, Tina
Alessandri, Cristiano
Longo, Agostina
Misasi, Roberta
Conti, Fabrizio
Sorice, Maurizio
author_facet Truglia, Simona
Capozzi, Antonella
Mancuso, Silvia
Manganelli, Valeria
Rapino, Luca
Riitano, Gloria
Recalchi, Serena
Colafrancesco, Serena
Ceccarelli, Fulvia
Garofalo, Tina
Alessandri, Cristiano
Longo, Agostina
Misasi, Roberta
Conti, Fabrizio
Sorice, Maurizio
author_sort Truglia, Simona
collection PubMed
description Antiphospholipid syndrome (APS), characterized by artherial and/or venous thrombosis, pregnancy morbidity and “antiphospholipid” antibodies (aPLs), is more common in women than in men, with a female to male ratio of about 3.5:1. Only few studies have investigated the clinical differences between male and female patients with APS. Therefore, this study was aimed to analyze the differences of clinical manifestations and laboratory tests, at diagnosis, between female and male APS patients and the clinical outcome. We enrolled 191 consecutive APS patients (125 with primary APS, PAPS, and 66 with secondary APS, SAPS) with a female predominant ratio of approximately 3:1 (142 vs 49). The prevalence of PAPS was higher in males than females (p<0.001). The analysis of aPL profile revealed that high IgM anti-cardiolipin (aCL) and high-medium IgG aCL titers were more frequent in males. In thrombotic APS peripheral arterial thrombosis was more common in male than female patients (p=0.049), as well as myocardial infarction (p=0.031). Multivariate analysis to correct for cardiovascular risk factors, high titer of aPLs and triple positivity for aPLs, revealed that the odds ratio for myocardial infarction in male was 3.77. Thus, APS may be considered as a disease in which serological (IgM titer) and clinical profiles are influenced by gender.
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spelling pubmed-92891582022-07-19 Relationship Between Gender Differences and Clinical Outcome in Patients With the Antiphospholipid Syndrome Truglia, Simona Capozzi, Antonella Mancuso, Silvia Manganelli, Valeria Rapino, Luca Riitano, Gloria Recalchi, Serena Colafrancesco, Serena Ceccarelli, Fulvia Garofalo, Tina Alessandri, Cristiano Longo, Agostina Misasi, Roberta Conti, Fabrizio Sorice, Maurizio Front Immunol Immunology Antiphospholipid syndrome (APS), characterized by artherial and/or venous thrombosis, pregnancy morbidity and “antiphospholipid” antibodies (aPLs), is more common in women than in men, with a female to male ratio of about 3.5:1. Only few studies have investigated the clinical differences between male and female patients with APS. Therefore, this study was aimed to analyze the differences of clinical manifestations and laboratory tests, at diagnosis, between female and male APS patients and the clinical outcome. We enrolled 191 consecutive APS patients (125 with primary APS, PAPS, and 66 with secondary APS, SAPS) with a female predominant ratio of approximately 3:1 (142 vs 49). The prevalence of PAPS was higher in males than females (p<0.001). The analysis of aPL profile revealed that high IgM anti-cardiolipin (aCL) and high-medium IgG aCL titers were more frequent in males. In thrombotic APS peripheral arterial thrombosis was more common in male than female patients (p=0.049), as well as myocardial infarction (p=0.031). Multivariate analysis to correct for cardiovascular risk factors, high titer of aPLs and triple positivity for aPLs, revealed that the odds ratio for myocardial infarction in male was 3.77. Thus, APS may be considered as a disease in which serological (IgM titer) and clinical profiles are influenced by gender. Frontiers Media S.A. 2022-07-04 /pmc/articles/PMC9289158/ /pubmed/35860235 http://dx.doi.org/10.3389/fimmu.2022.932181 Text en Copyright © 2022 Truglia, Capozzi, Mancuso, Manganelli, Rapino, Riitano, Recalchi, Colafrancesco, Ceccarelli, Garofalo, Alessandri, Longo, Misasi, Conti and Sorice https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Truglia, Simona
Capozzi, Antonella
Mancuso, Silvia
Manganelli, Valeria
Rapino, Luca
Riitano, Gloria
Recalchi, Serena
Colafrancesco, Serena
Ceccarelli, Fulvia
Garofalo, Tina
Alessandri, Cristiano
Longo, Agostina
Misasi, Roberta
Conti, Fabrizio
Sorice, Maurizio
Relationship Between Gender Differences and Clinical Outcome in Patients With the Antiphospholipid Syndrome
title Relationship Between Gender Differences and Clinical Outcome in Patients With the Antiphospholipid Syndrome
title_full Relationship Between Gender Differences and Clinical Outcome in Patients With the Antiphospholipid Syndrome
title_fullStr Relationship Between Gender Differences and Clinical Outcome in Patients With the Antiphospholipid Syndrome
title_full_unstemmed Relationship Between Gender Differences and Clinical Outcome in Patients With the Antiphospholipid Syndrome
title_short Relationship Between Gender Differences and Clinical Outcome in Patients With the Antiphospholipid Syndrome
title_sort relationship between gender differences and clinical outcome in patients with the antiphospholipid syndrome
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289158/
https://www.ncbi.nlm.nih.gov/pubmed/35860235
http://dx.doi.org/10.3389/fimmu.2022.932181
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