Neutrophils: New Critical Regulators of Glioma

In cancer, neutrophils are an important part of the tumour microenvironment (TME). Previous studies have shown that circulating and infiltrating neutrophils are associated with malignant progression and immunosuppression in gliomas. However, recent studies have shown that neutrophils have an antitum...

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Autores principales: Wang, Guanyu, Wang, Jinpeng, Niu, Chaoshi, Zhao, Yan, Wu, Pengfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289230/
https://www.ncbi.nlm.nih.gov/pubmed/35860278
http://dx.doi.org/10.3389/fimmu.2022.927233
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author Wang, Guanyu
Wang, Jinpeng
Niu, Chaoshi
Zhao, Yan
Wu, Pengfei
author_facet Wang, Guanyu
Wang, Jinpeng
Niu, Chaoshi
Zhao, Yan
Wu, Pengfei
author_sort Wang, Guanyu
collection PubMed
description In cancer, neutrophils are an important part of the tumour microenvironment (TME). Previous studies have shown that circulating and infiltrating neutrophils are associated with malignant progression and immunosuppression in gliomas. However, recent studies have shown that neutrophils have an antitumour effect. In this review, we focus on the functional roles of neutrophils in the circulation and tumour sites in patients with glioma. The mechanisms of neutrophil recruitment, immunosuppression and the differentiation of neutrophils are discussed. Finally, the potential of neutrophils as clinical biomarkers and therapeutic targets is highlighted. This review can help us gain a deeper and systematic understanding of the role of neutrophils, and provide new insights for treatment in gliomas.
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spelling pubmed-92892302022-07-19 Neutrophils: New Critical Regulators of Glioma Wang, Guanyu Wang, Jinpeng Niu, Chaoshi Zhao, Yan Wu, Pengfei Front Immunol Immunology In cancer, neutrophils are an important part of the tumour microenvironment (TME). Previous studies have shown that circulating and infiltrating neutrophils are associated with malignant progression and immunosuppression in gliomas. However, recent studies have shown that neutrophils have an antitumour effect. In this review, we focus on the functional roles of neutrophils in the circulation and tumour sites in patients with glioma. The mechanisms of neutrophil recruitment, immunosuppression and the differentiation of neutrophils are discussed. Finally, the potential of neutrophils as clinical biomarkers and therapeutic targets is highlighted. This review can help us gain a deeper and systematic understanding of the role of neutrophils, and provide new insights for treatment in gliomas. Frontiers Media S.A. 2022-07-04 /pmc/articles/PMC9289230/ /pubmed/35860278 http://dx.doi.org/10.3389/fimmu.2022.927233 Text en Copyright © 2022 Wang, Wang, Niu, Zhao and Wu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Wang, Guanyu
Wang, Jinpeng
Niu, Chaoshi
Zhao, Yan
Wu, Pengfei
Neutrophils: New Critical Regulators of Glioma
title Neutrophils: New Critical Regulators of Glioma
title_full Neutrophils: New Critical Regulators of Glioma
title_fullStr Neutrophils: New Critical Regulators of Glioma
title_full_unstemmed Neutrophils: New Critical Regulators of Glioma
title_short Neutrophils: New Critical Regulators of Glioma
title_sort neutrophils: new critical regulators of glioma
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289230/
https://www.ncbi.nlm.nih.gov/pubmed/35860278
http://dx.doi.org/10.3389/fimmu.2022.927233
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