Negative Regulation of Zap70 by Lck Forms the Mechanistic Basis of Differential Expression in CD4 and CD8 T Cells

Lck and Zap70, two non-receptor tyrosine kinases, play a crucial role in the regulation of membrane proximal TCR signaling critical for thymic selection, CD4/CD8 lineage choice and mature T cell function. Signal initiation upon TCR/CD3 and peptide/MHC interaction induces Lck-mediated phosphorylation...

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Detalles Bibliográficos
Autores principales: Damen, Hassan, Tebid, Christian, Viens, Melissa, Roy, Denis-Claude, Dave, Vibhuti P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289233/
https://www.ncbi.nlm.nih.gov/pubmed/35860252
http://dx.doi.org/10.3389/fimmu.2022.935367

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289233/
https://www.ncbi.nlm.nih.gov/pubmed/35860252
http://dx.doi.org/10.3389/fimmu.2022.935367

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