Cargando…

Negative Regulation of Zap70 by Lck Forms the Mechanistic Basis of Differential Expression in CD4 and CD8 T Cells

Lck and Zap70, two non-receptor tyrosine kinases, play a crucial role in the regulation of membrane proximal TCR signaling critical for thymic selection, CD4/CD8 lineage choice and mature T cell function. Signal initiation upon TCR/CD3 and peptide/MHC interaction induces Lck-mediated phosphorylation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Damen, Hassan, Tebid, Christian, Viens, Melissa, Roy, Denis-Claude, Dave, Vibhuti P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289233/ https://www.ncbi.nlm.nih.gov/pubmed/35860252 http://dx.doi.org/10.3389/fimmu.2022.935367

Ejemplares similares

Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT
por: Lo, Wan-Lin, et al.
Publicado: (2018)

Biophysical basis underlying dynamic Lck activation visualized by ZapLck FRET biosensor
por: Wan, Rongxue, et al.
Publicado: (2019)

G-CSF inhibits LFA-1-mediated CD4(+) T cell functions by inhibiting Lck and ZAP-70
por: Zhao, Shasha, et al.
Publicado: (2017)

Syk and ZAP-70 mediate recruitment of p56lck/CD4 to the activated T cell receptor/CD3/zeta complex
Publicado: (1995)

Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes
Publicado: (1996)

RhoH Regulates Subcellular Localization of ZAP-70 and Lck in T Cell Receptor Signaling
por: Chae, Hee-Don, et al.
Publicado: (2010)

p56lck interacts via its src homology 2 domain with the ZAP-70 kinase
Publicado: (1994)

ZAP-70 Protein Promotes Tyrosine Phosphorylation of T Cell Receptor Signaling Motifs (ITAMs) in Immature CD4(+)8(+) Thymocytes with Limiting p56(lck)
por: Ashe, Jennifer M., et al.
Publicado: (1999)

A Cysteine Residue within the Kinase Domain of Zap70 Regulates Lck Activity and Proximal TCR Signaling
por: Schultz, Annika, et al.
Publicado: (2022)

A Story of Kinases and Adaptors: The Role of Lck, ZAP-70 and LAT in Switch Panel Governing T-Cell Development and Activation
por: Fernández-Aguilar, Luis M., et al.
Publicado: (2023)

The Structural Basis for Activation and Inhibition of ZAP-70 Kinase Domain
por: Huber, Roland G., et al.
Publicado: (2015)

T cells from late tumor-bearing mice express normal levels of p56lck, p59fyn, ZAP-70, and CD3 zeta despite suppressed cytolytic activity
Publicado: (1995)

Immune synapse formation requires ZAP-70 recruitment by ezrin and CD43 removal by moesin
por: Ilani, Tal, et al.
Publicado: (2007)

CCL5 promotes LFA-1 expression in Th17 cells and induces LCK and ZAP70 activation in a mouse model of Parkinson’s disease
por: Zhao, Jingwei, et al.
Publicado: (2023)

Evaluation of lymphocytes CD4+ and CD8+ and expression of ZAP-70 kinase on CD3+ and CD19+ lymphocytes in obese patients undergoing laparoscopic cholecystectomy
por: Torres, Kamil, et al.
Publicado: (2012)

Reconstitution of T cell receptor signaling in ZAP-70-deficient cells by retroviral transduction of the ZAP-70 gene
Publicado: (1996)

Quantitative Phosphoproteome Analysis Unveils LAT as a Modulator of CD3ζ and ZAP-70 Tyrosine Phosphorylation
por: Salek, Mogjiborahman, et al.
Publicado: (2013)

High CD74 expression correlates with ZAP70 expression in B cell chronic lymphocytic leukemia patients
por: Butrym, Aleksandra, et al.
Publicado: (2013)

Combined analysis of ZAP-70 and CD38 expression in sudanese patients with B-cell chronic lymphocytic leukemia
por: Basabaeen, Ameen Abdulaziz, et al.
Publicado: (2019)

Coclustering CD45 with CD4 or CD8 alters the phosphorylation and kinase activity of p56lck
Publicado: (1990)

Restricting Zap70 Expression to CD4(+)CD8(+) Thymocytes Reveals a T Cell Receptor–dependent Proofreading Mechanism Controlling the Completion of Positive Selection
por: Liu, Xiaolong, et al.
Publicado: (2003)

ZAP-70 Restoration in Mice by In Vivo Thymic Electroporation
por: Irla, Magali, et al.
Publicado: (2008)

Comparison of CD3e Antibody and CD3e-sZAP Immunotoxin Treatment in Mice Identifies sZAP as the Main Driver of Vascular Leakage
por: Kim, Shihyoung, et al.
Publicado: (2022)

Inhibition of ZAP-70 Kinase Activity via an Analog-sensitive Allele Blocks T Cell Receptor and CD28 Superagonist Signaling
por: Levin, Susan E., et al.
Publicado: (2008)

The CD3 chains of the T cell antigen receptor associate with the ZAP-70 tyrosine kinase and are tyrosine phosphorylated after receptor stimulation
Publicado: (1993)

ZAP-70 expression is associated with increased CD4 central memory T cells in chronic lymphocytic leukemia: cross-sectional study
por: Correia, Rodolfo Patussi, et al.
Publicado: (2018)

Ligand engaged TCR is triggered by Lck not associated with CD8 coreceptor
por: Casas, Javier, et al.
Publicado: (2014)

CD8 beta chain influences CD8 alpha chain-associated Lck kinase activity
Publicado: (1995)

Lck Mediates Signal Transmission from CD59 to the TCR/CD3 Pathway in Jurkat T Cells
por: Lipp, Anna M., et al.
Publicado: (2014)

How the Discovery of the CD4/CD8-p56(lck) Complexes Changed Immunology and Immunotherapy
por: Rudd, Christopher E.
Publicado: (2021)

CD8β Endows CD8 with Efficient Coreceptor Function by Coupling T Cell Receptor/CD3 to Raft-associated CD8/p56(lck) Complexes
por: Arcaro, Alexandre, et al.
Publicado: (2001)

ZAP-70 Shapes the Immune Microenvironment in B Cell Malignancies
por: Chen, Jingyu, et al.
Publicado: (2020)

Dephosphorylation accelerates the dissociation of ZAP70 from the T cell receptor
por: Goyette, Jesse, et al.
Publicado: (2022)

An evolutionary divergent thermodynamic brake in ZAP-70 fine-tunes the kinetic proofreading in T cells
por: Gangopadhyay, Kaustav, et al.
Publicado: (2022)

Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules
Publicado: (1993)

CD4-mediated enhancement or inhibition of T cell activation does not require the CD4:p56lck association
Publicado: (1994)

Distinct roles for Syk and ZAP-70 during early thymocyte development
por: Palacios, Emil H., et al.
Publicado: (2007)

Regulation of ZAP-70 Intracellular Localization: Visualization with the Green Fluorescent Protein
por: Sloan-Lancaster, Joanne, et al.
Publicado: (1997)

Increased ZAP70 Is Involved in Dry Skin Pruritus in Aged Mice
por: Zhao, Nan, et al.
Publicado: (2016)

Cytokine Contents in Chronic Lymphocytic Leukemia: Association with ZAP70 Expression
por: Işıksaçan, Nilgün, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_vdl7r0fj2qsqu7a6oq7oqgpkqm