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Clinical profile and biochemical abnormalities in brucellosis: A cross-sectional study

INTRODUCTION: Brucellosis is the commonest zoonotic disease worldwide and a common public health problem in Nepal. Because of the highly variable clinical presentation and non-specific manifestations, it remains a big challenge for clinicians from developing countries. Brucellosis has a tropism for...

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Autores principales: Shrestha, Sanjeeb, Karn, Mitesh, Regmi, Sanjib Mani, Nagila, Amar, Pahari, Sandip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289301/
https://www.ncbi.nlm.nih.gov/pubmed/35860119
http://dx.doi.org/10.1016/j.amsu.2022.103922
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author Shrestha, Sanjeeb
Karn, Mitesh
Regmi, Sanjib Mani
Nagila, Amar
Pahari, Sandip
author_facet Shrestha, Sanjeeb
Karn, Mitesh
Regmi, Sanjib Mani
Nagila, Amar
Pahari, Sandip
author_sort Shrestha, Sanjeeb
collection PubMed
description INTRODUCTION: Brucellosis is the commonest zoonotic disease worldwide and a common public health problem in Nepal. Because of the highly variable clinical presentation and non-specific manifestations, it remains a big challenge for clinicians from developing countries. Brucellosis has a tropism for the reticuloendothelial system, the liver is frequently involved. There is a paucity of data about the laboratory and clinical findings of human Brucellosis from Nepal. To address this knowledge gap, we conducted this study to find out the clinical profile and biochemical abnormalities of patients with brucellosis at a tertiary-care teaching hospital in western Nepal. METHODS: A cross-sectional study was carried out at Gandaki Medical College Teaching Hospital, Pokhara, Nepal. All patients admitted to the in-patient department of our hospital with probable or definitive diagnoses of brucellosis were included. We excluded those who did not consent to their participation in our study, those who were under 18 years of age, and those who had deranged liver function due to other pre-existing illnesses. Descriptive statistics were used to analyze the data in terms of demography, clinical manifestations, and laboratory parameters. RESULTS: There was a total of 40 confirmed cases of Brucellosis (age: 18–66 years) during the study period. More than half (55%, n = 22) of the study participants were males and most of them lived in a rural setting (77.5%, n = 31). Most of them (70%, n = 28) gave history of ingestion of high-risk food. The commonest clinical findings were fever with/out chills (90%, n = 36) followed by nausea/vomiting (72.5%, n = 29), headache (40%, n = 16) and malaise (37.5, n = 15). Liver function was deranged in a majority of the patients, the common parameters being Alkaline phosphatase in 96% (n = 38) cases, followed by SGOT (62.5%, n = 25), leukocytosis (57.5%, n = 23), total bilirubin (52.5%, n = 21) and SGPT (37.5%, n = 15). Characteristic increment (more than two folds of the upper limit of normal) was observed for alkaline phosphatase. CONCLUSION: The reticuloendothelial system is frequently involved in brucellosis. Notable changes were observed in liver function and hematological parameters in a majority of the participants in our study. These findings highlight the need for the implementation of effective control programs to address this problem in the Nepalese context.
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spelling pubmed-92893012022-07-19 Clinical profile and biochemical abnormalities in brucellosis: A cross-sectional study Shrestha, Sanjeeb Karn, Mitesh Regmi, Sanjib Mani Nagila, Amar Pahari, Sandip Ann Med Surg (Lond) Cross-sectional Study INTRODUCTION: Brucellosis is the commonest zoonotic disease worldwide and a common public health problem in Nepal. Because of the highly variable clinical presentation and non-specific manifestations, it remains a big challenge for clinicians from developing countries. Brucellosis has a tropism for the reticuloendothelial system, the liver is frequently involved. There is a paucity of data about the laboratory and clinical findings of human Brucellosis from Nepal. To address this knowledge gap, we conducted this study to find out the clinical profile and biochemical abnormalities of patients with brucellosis at a tertiary-care teaching hospital in western Nepal. METHODS: A cross-sectional study was carried out at Gandaki Medical College Teaching Hospital, Pokhara, Nepal. All patients admitted to the in-patient department of our hospital with probable or definitive diagnoses of brucellosis were included. We excluded those who did not consent to their participation in our study, those who were under 18 years of age, and those who had deranged liver function due to other pre-existing illnesses. Descriptive statistics were used to analyze the data in terms of demography, clinical manifestations, and laboratory parameters. RESULTS: There was a total of 40 confirmed cases of Brucellosis (age: 18–66 years) during the study period. More than half (55%, n = 22) of the study participants were males and most of them lived in a rural setting (77.5%, n = 31). Most of them (70%, n = 28) gave history of ingestion of high-risk food. The commonest clinical findings were fever with/out chills (90%, n = 36) followed by nausea/vomiting (72.5%, n = 29), headache (40%, n = 16) and malaise (37.5, n = 15). Liver function was deranged in a majority of the patients, the common parameters being Alkaline phosphatase in 96% (n = 38) cases, followed by SGOT (62.5%, n = 25), leukocytosis (57.5%, n = 23), total bilirubin (52.5%, n = 21) and SGPT (37.5%, n = 15). Characteristic increment (more than two folds of the upper limit of normal) was observed for alkaline phosphatase. CONCLUSION: The reticuloendothelial system is frequently involved in brucellosis. Notable changes were observed in liver function and hematological parameters in a majority of the participants in our study. These findings highlight the need for the implementation of effective control programs to address this problem in the Nepalese context. Elsevier 2022-06-11 /pmc/articles/PMC9289301/ /pubmed/35860119 http://dx.doi.org/10.1016/j.amsu.2022.103922 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Cross-sectional Study
Shrestha, Sanjeeb
Karn, Mitesh
Regmi, Sanjib Mani
Nagila, Amar
Pahari, Sandip
Clinical profile and biochemical abnormalities in brucellosis: A cross-sectional study
title Clinical profile and biochemical abnormalities in brucellosis: A cross-sectional study
title_full Clinical profile and biochemical abnormalities in brucellosis: A cross-sectional study
title_fullStr Clinical profile and biochemical abnormalities in brucellosis: A cross-sectional study
title_full_unstemmed Clinical profile and biochemical abnormalities in brucellosis: A cross-sectional study
title_short Clinical profile and biochemical abnormalities in brucellosis: A cross-sectional study
title_sort clinical profile and biochemical abnormalities in brucellosis: a cross-sectional study
topic Cross-sectional Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289301/
https://www.ncbi.nlm.nih.gov/pubmed/35860119
http://dx.doi.org/10.1016/j.amsu.2022.103922
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