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Calcium Ions Signaling: Targets for Attack and Utilization by Viruses

Calcium, as a second intracellular messenger, participate in various physiological and biochemical processes, including cell growth and proliferation, energy metabolism, information transfer, cell death, and immune response. Ca(2+) channels or pumps in plasma and organelle membranes and Ca(2+)-relat...

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Autores principales: Qu, Yang, Sun, Yingjie, Yang, Zengqi, Ding, Chan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289559/
https://www.ncbi.nlm.nih.gov/pubmed/35859744
http://dx.doi.org/10.3389/fmicb.2022.889374
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author Qu, Yang
Sun, Yingjie
Yang, Zengqi
Ding, Chan
author_facet Qu, Yang
Sun, Yingjie
Yang, Zengqi
Ding, Chan
author_sort Qu, Yang
collection PubMed
description Calcium, as a second intracellular messenger, participate in various physiological and biochemical processes, including cell growth and proliferation, energy metabolism, information transfer, cell death, and immune response. Ca(2+) channels or pumps in plasma and organelle membranes and Ca(2+)-related proteins maintain Ca(2+) homeostasis by regulating Ca(2+) inflow, outflow and buffering to avoid any adverse effects caused by Ca(2+) overload or depletion. Thus, Ca(2+) signaling also provides a target for virus invasion, replication, proliferation and release. After hijacking the host cell, viruses exploit Ca(2+) signaling to regulate apoptosis and resist host immunity to establish persistent infection. In this review, we discuss cellular Ca(2+) signaling and channels, interaction of calcium-associated proteins with viruses, and host cell fate, as well as the role of Ca(2+) in cell death and antiviral response during viral infection.
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spelling pubmed-92895592022-07-19 Calcium Ions Signaling: Targets for Attack and Utilization by Viruses Qu, Yang Sun, Yingjie Yang, Zengqi Ding, Chan Front Microbiol Microbiology Calcium, as a second intracellular messenger, participate in various physiological and biochemical processes, including cell growth and proliferation, energy metabolism, information transfer, cell death, and immune response. Ca(2+) channels or pumps in plasma and organelle membranes and Ca(2+)-related proteins maintain Ca(2+) homeostasis by regulating Ca(2+) inflow, outflow and buffering to avoid any adverse effects caused by Ca(2+) overload or depletion. Thus, Ca(2+) signaling also provides a target for virus invasion, replication, proliferation and release. After hijacking the host cell, viruses exploit Ca(2+) signaling to regulate apoptosis and resist host immunity to establish persistent infection. In this review, we discuss cellular Ca(2+) signaling and channels, interaction of calcium-associated proteins with viruses, and host cell fate, as well as the role of Ca(2+) in cell death and antiviral response during viral infection. Frontiers Media S.A. 2022-07-04 /pmc/articles/PMC9289559/ /pubmed/35859744 http://dx.doi.org/10.3389/fmicb.2022.889374 Text en Copyright © 2022 Qu, Sun, Yang and Ding. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Qu, Yang
Sun, Yingjie
Yang, Zengqi
Ding, Chan
Calcium Ions Signaling: Targets for Attack and Utilization by Viruses
title Calcium Ions Signaling: Targets for Attack and Utilization by Viruses
title_full Calcium Ions Signaling: Targets for Attack and Utilization by Viruses
title_fullStr Calcium Ions Signaling: Targets for Attack and Utilization by Viruses
title_full_unstemmed Calcium Ions Signaling: Targets for Attack and Utilization by Viruses
title_short Calcium Ions Signaling: Targets for Attack and Utilization by Viruses
title_sort calcium ions signaling: targets for attack and utilization by viruses
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289559/
https://www.ncbi.nlm.nih.gov/pubmed/35859744
http://dx.doi.org/10.3389/fmicb.2022.889374
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