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Calcium Ions Signaling: Targets for Attack and Utilization by Viruses
Calcium, as a second intracellular messenger, participate in various physiological and biochemical processes, including cell growth and proliferation, energy metabolism, information transfer, cell death, and immune response. Ca(2+) channels or pumps in plasma and organelle membranes and Ca(2+)-relat...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289559/ https://www.ncbi.nlm.nih.gov/pubmed/35859744 http://dx.doi.org/10.3389/fmicb.2022.889374 |
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author | Qu, Yang Sun, Yingjie Yang, Zengqi Ding, Chan |
author_facet | Qu, Yang Sun, Yingjie Yang, Zengqi Ding, Chan |
author_sort | Qu, Yang |
collection | PubMed |
description | Calcium, as a second intracellular messenger, participate in various physiological and biochemical processes, including cell growth and proliferation, energy metabolism, information transfer, cell death, and immune response. Ca(2+) channels or pumps in plasma and organelle membranes and Ca(2+)-related proteins maintain Ca(2+) homeostasis by regulating Ca(2+) inflow, outflow and buffering to avoid any adverse effects caused by Ca(2+) overload or depletion. Thus, Ca(2+) signaling also provides a target for virus invasion, replication, proliferation and release. After hijacking the host cell, viruses exploit Ca(2+) signaling to regulate apoptosis and resist host immunity to establish persistent infection. In this review, we discuss cellular Ca(2+) signaling and channels, interaction of calcium-associated proteins with viruses, and host cell fate, as well as the role of Ca(2+) in cell death and antiviral response during viral infection. |
format | Online Article Text |
id | pubmed-9289559 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92895592022-07-19 Calcium Ions Signaling: Targets for Attack and Utilization by Viruses Qu, Yang Sun, Yingjie Yang, Zengqi Ding, Chan Front Microbiol Microbiology Calcium, as a second intracellular messenger, participate in various physiological and biochemical processes, including cell growth and proliferation, energy metabolism, information transfer, cell death, and immune response. Ca(2+) channels or pumps in plasma and organelle membranes and Ca(2+)-related proteins maintain Ca(2+) homeostasis by regulating Ca(2+) inflow, outflow and buffering to avoid any adverse effects caused by Ca(2+) overload or depletion. Thus, Ca(2+) signaling also provides a target for virus invasion, replication, proliferation and release. After hijacking the host cell, viruses exploit Ca(2+) signaling to regulate apoptosis and resist host immunity to establish persistent infection. In this review, we discuss cellular Ca(2+) signaling and channels, interaction of calcium-associated proteins with viruses, and host cell fate, as well as the role of Ca(2+) in cell death and antiviral response during viral infection. Frontiers Media S.A. 2022-07-04 /pmc/articles/PMC9289559/ /pubmed/35859744 http://dx.doi.org/10.3389/fmicb.2022.889374 Text en Copyright © 2022 Qu, Sun, Yang and Ding. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Qu, Yang Sun, Yingjie Yang, Zengqi Ding, Chan Calcium Ions Signaling: Targets for Attack and Utilization by Viruses |
title | Calcium Ions Signaling: Targets for Attack and Utilization by Viruses |
title_full | Calcium Ions Signaling: Targets for Attack and Utilization by Viruses |
title_fullStr | Calcium Ions Signaling: Targets for Attack and Utilization by Viruses |
title_full_unstemmed | Calcium Ions Signaling: Targets for Attack and Utilization by Viruses |
title_short | Calcium Ions Signaling: Targets for Attack and Utilization by Viruses |
title_sort | calcium ions signaling: targets for attack and utilization by viruses |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289559/ https://www.ncbi.nlm.nih.gov/pubmed/35859744 http://dx.doi.org/10.3389/fmicb.2022.889374 |
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